Relation Between Emotional Regulation and Impulsivity in Cannabis Use Disorder and the Morphometric Changes in Brain Reward System Structures
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 66
- 试验地点
- 1
- 主要终点
- degree of impulsivity in addicts
研究概览
简要总结
cannabis addiction is a major health hazard that has its effect on personality and behavior including the impulsivity and emotional regulation. It also has its effect on both the structure and function of different brain regions involved in brain reward system.
the aim of the study is to study the emotional regulation and impulsivity among people with cannabis addiction studying the change in the volume of brain reward system structures' volume in relation to cannabis addiction and the change in the mentioned behavioral traits.
详细描述
Introduction:
Cannabis sativa is a widely used drug comprising a broad spectrum of usage ranging from recreational users to chronic addicts.
Dependence on cannabis is considered a major global health related issue. Cannabis is still considered the most used psychoactive substance worldwide with an estimated 2.8-5.1 % of global adult population has used cannabis in 2019.
Epidemiological studies show that cannabis is the leading drug of abuse in Egypt and in Upper Egypt. Prevalence of cannabis dependence is estimated to be 7.4% in Egypt and 6.66 % in Upper Egypt.
Cannabis dependence is associated with multiple neurobehavioral abnormalities which can be considered as a psychological determinants of cannabis dependence .
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Age above 18 years.
- •Clearly consenting to participate in the study. . patient with substance use disorder
排除标准
- •Intoxication or withdrawal state.
- •Comorbid Axis I psychiatric disorder.
- •any current or past neurological disorder.
结局指标
主要结局
degree of impulsivity in addicts
时间窗: 7 months
the UPPS-P scale was used to measure the degree of impulsivity. it is a 20-item scale designed to assess five distinct personality traits to impulsive behavior: Negative Urgency, Lack of Perseverance, Lack of Premeditation, Positive Urgency and Sensation Seeking
measuring the volume of prefrontal cortex in addicts
时间窗: 7 months
MRI brain with voxel based morphometry was used in measuring the volume of different brain regions involved in the brain reward system
次要结局
未报告次要终点
研究者
Sayed Mostafa
Lecturer of psychiatry
Assiut University