Relationship of Retinal and Visual Cortex Structure and Visual Acuity After Congenital Cataract Surgery

• Conditions: Congenital Cataract

• Registration Number: NCT04976608
• Lead Sponsor: Wenzhou Medical University

Brief Summary

To evaluate the influence of the visual acuity after congenital surgery on the retinal and visual cortex structure.

Detailed Description

According to the visual acuity after congenital cataract surgery, 30 patients are divided into 3 groups.SD-OCT and MRI were used to measure the parameters of the retina and the visual cortex, to compare the differences between different groups, and to analyze the relationship between the structure of the retina and the visual cortex and visual acuity.

Study Timeline

• Study Start: 2021-06-16
• Status Verified: 2021-07
• Study First Submitted: 2021-07-05
• Study First Submitted QC: 2021-07-15
• Last Update Submitted: 2021-07-15
• Study First Posted: 2021-07-26
• Last Update Posted: 2021-07-26
• Primary Completion: 2021-12-30
• Study Completion: 2021-12-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• age of 4-60 years
• Congenital cataract surgery is planned
• The operation was successful without any complications
• Can cooperate well with OCT and MRI examinations

Exclusion Criteria

• Intraoperative and postoperative complications include glaucoma, retinal, corneal, or refractive medium diseases
• Behavioral, cognitive impairment
• Developmental delay

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Macular thickness	2021.12.30	Scan the 3.0mm diameter ETDRS ring area in the macular area with SD-OCT.
Subfoveal choroidal thickness	2021.12.30	Scan the Subfoveal choroid in enhanced scan mode with SD-OCT.
Retinal nerve fiber layer thickness	2021.12.30	Scan concentric circles with a length of 3.4mm and a diameter ranging from 2.5mm to 4.0mm in 12 directions centered on the optic disc with SD-OCT.
The volume of the lateral geniculate body	2021.12.30	Measure the volume of the lateral geniculate body by T1 phase scan of MRI
The volume of the brodmann 17,18,19 area	2021.12.30	Masure the volume of the brodmann 17,18,19 area by T1 phase scan of MRI
The FA of the white matter fiber bundle	2021.12.30	Measure the Fraction Anisotropy of the white matter fiber bundle related to visual signal transduction by DWI scan of MRI

Trial Locations

Locations (1)

Eye Hospital of Wenzhou Medical College; 🇨🇳 Wenzhou, Zhejiang, China