Histopathological Changes in Mycosis Fungoides
- Conditions
- Mycosis Fungoides
- Interventions
- Diagnostic Test: biopsy
- Registration Number
- NCT05904522
- Lead Sponsor
- Bezmialem Vakif University
- Brief Summary
Patients with mycosis fungoides stage 1A disease have patch and plaque lesions less than %10 of body skin area. Aim of the study is to compare lesional and non-lesional skin of mycosis fungoides patients, and to decide if the systemic treatment is better or local treatment is better for them. Two biopsies for each patient were taken from lesional and non-lesional skin area.
- Detailed Description
Patients with mycosis fungoides stage 1A disease have patch and plaque lesions less than %10 of body skin area. Aim of the study is to compare lesional and non-lesional skin of mycosis fungoides patients, and to decide if the systemic treatment is better or local treatment is better for them. Two biopsies for each patient were taken from lesional and non-lesional skin area.
Biopsies will be taken from lesional and non-lesional skin of the patients in the dermatology clinic and sent to laboratory for histopathologic examination.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 10
- Histopathologically confirmed mycosis fungoides stage 1A patients
- Mycosis fungoides patients with other stages
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description lesional skin biopsy lesional skin of mycosis fungoides stage 1A patients non-lesional skin biopsy non-lesional skin of mycosis fungoides stage 1A patients
- Primary Outcome Measures
Name Time Method CD4+ T cells in epidermis 6 months Histopathologically clonal T lymphocytes in epidermis reveal the diagnosis. If they are seen in non-lesional skin, then lesional specific local treatment is not enough for the disease.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Bezmialem Vakif University Hospital
🇹🇷Istanbul, Turkey