Effect of single or combined treatment of naproxen, acetaminophen and omega- 3 on Knee osteoarthritis
Phase 2
- Conditions
- Knee osteoarthritis.Gonarthrosis [arthrosis of knee],Primary gonarthrosis, bilateral
- Registration Number
- IRCT2012102610799N2
- Lead Sponsor
- Vice chancellor of research, Yasuj University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 210
Inclusion Criteria
Inclusion criteria include idiopathic knee osteoarthritis in 45-65 years persons old with mild to moderate knee pain.
Exclusion criteria include rheumatic arthritis, septic arthritis, previous joint trauma, acute joint trauma, old fractures of joint, joint anomalies, alcohol abuse, hepatic insufficiency, heparin use, steroid use during 2 months ago, steroid or hyalgan injection into the joint during 9 months ago, taking oral steroid in 8 days ago, gastrointestinal bleeding, renal insufficiency, pregnancy or lactation woman, hypersensitivity to remember drugs, severe respiratory insufficiency and knee prosthesis.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pain. Timepoint: Before starting of intervention. Method of measurement: Visual analogue scale.;Joint stiffness. Timepoint: Before treatment. Method of measurement: WOMAC.;Physical functions. Timepoint: Before treatment. Method of measurement: WOMAC.;Pain. Timepoint: Before treatment. Method of measurement: WOMAC.
- Secondary Outcome Measures
Name Time Method Pain. Timepoint: After end of intervention(6 weeks after start of intervention). Method of measurement: Visual analogue scale.;Joint stiffness. Timepoint: After end of treatment. Method of measurement: WOMAC.;Physical functions. Timepoint: After end of treatment. Method of measurement: WOMAC.;Pain. Timepoint: After end of treatment. Method of measurement: Visual analogue scale.