A Randomized, Prospective, Double-blind, Placebo-controlled Trial of the Effect of Diltiazem Gel on Pain after Hemorrhoidectomy

Not Applicable

• Conditions: Goligher 3rd or 4th degree hemorrhoids

• Registration Number: JPRN-UMIN000010658
• Lead Sponsor: Kameda Medical Center

Brief Summary

The postoperative pain scores tended lower in the diltiazem group during defecation. Oral analgesic tablets consumed was higher in the placebo group when considered on a daily basis, but the difference did not reach a statistical significance. Total incidence of complications was significantly higher in the diltiazem group than in the placebo group, although each incidence of complication was not significantly different between the groups. There was no significant difference in the incidence of edema on 1 week, wound healing on week 3, or anal stenosis on week 6. Patient satisfaction score was not different between the groups.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2012-05-04
• Study Start: 2014-01-01
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Not provided

Exclusion Criteria

patients with a history of current calcium channel blocker use, ischemic heart disease, pregnancy, severe hypertension, orthostatic hypotension, previous anal operation, incarcerated hemorrhoid, or American Society of Anesthesiologists physical status (ASA-PS) classification 3 and 4

Study & Design

• Study Type: Interventional,observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The postoperative pain scores,oral analgesic tablets consumed, wound healing, and patient satisfaction score.