Prospective, Randomized, Double Blind Study Comparing IV vs PO Acetaminophen in Patients Undergoing Lumbar Discectomy
- Registration Number
- NCT02067442
- Lead Sponsor
- Thomas Jefferson University
- Brief Summary
Both intravenous and oral acetaminophen have been shown to reduce post-operative pain scores when given preoperatively. This study investigates if there is a difference between the intravenous and the oral forms when given preoperatively to patients undergoing lumbar microdiscectomy. We hypothesize that the intravenous formulation does not improve pain scores or decrease opioid consumption during the first postoperative day compared to the oral formulation.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 100
- Single level lumbar micro disk surgery
- Ages 18-65
Exclusion Criteria
- morbid obesity
- prior back surgery
- opioid tolerance
- pregnancy
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description oral acetaminophen oral acetaminophen Patients in this arm of the study will receive oral acetaminophen and an IV placebo intravenous acetaminophen intravenous acetaminophen Patients in this arm of the study will receive IV acetaminophen and an oral placebo
- Primary Outcome Measures
Name Time Method Postoperative pain scores Day of surgery Pain scores are measured using a visual analog scale with patient at rest and also with movement of the lower extremities at four separate times following surgery.
- Secondary Outcome Measures
Name Time Method Quantity of intraoperative and postoperative opioids administered. Day of surgery All doses of opioids given on the day of surgery will be recorded.
Trial Locations
- Locations (1)
Thomas Jefferson University Hopsital
🇺🇸Philadelphia, Pennsylvania, United States