Efficacy of Acetaminophen-ibuprofen Combination on the Postoperative Pain After Laparoscopic Gynecology Surgery

Not Applicable

Recruiting

• Conditions: Gynecologic Disease
• Interventions: Drug: Acetaminophen; Drug: Ibuprofen

• Registration Number: NCT05509244
• Lead Sponsor: The Catholic University of Korea

Brief Summary

Acetaminophen and ibuprofen has been safely used for a long time and reduces postoperative pain and opioid dosages. Investigators are planning to compare the efficacy of 1) acetaminophen only and 2) acetaminophen and ibuprofen combination at postoperative pain after laparoscopic gynecologic surgery.

Detailed Description

Acetaminophen and ibuprofen has been safely used for a long time and reduces postoperative pain and opioid dosages. Investigators are planning to compare the efficacy of 1) acetaminophen 1g only and 2) the combination of acetaminophen 1g and ibuprofen 300mg at postoperative pain after laparoscopic gynecologic surgery. Some recovery valuables such as the postoperative pain and opioid requirements will be assessed.

Study Timeline

• Study First Submitted: 2022-08-17
• Study First Submitted QC: 2022-08-18
• Study First Posted: 2022-08-22
• Status Verified: 2022-09
• Study Start: 2022-09-09
• Last Update Submitted: 2022-09-22
• Last Update Posted: 2022-09-26
• Primary Completion: 2023-08-24
• Study Completion: 2023-08-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: Female
• Target Recruitment: 64

Inclusion Criteria

• Patients scheduled gynecologic laparoscopic surgery

Exclusion Criteria

1. Refusal to be enrolled in the study
2. Emergency surgery
3. On chronic pain medications
4. Psychiatric disorders
5. Pregnant, lactating women
6. Allergy or contraindication to the medication drugs

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
control group	Acetaminophen	acetaminophen 1g iv dripping
experimental group	Acetaminophen	the combination of acetaminophen 1g and ibuprofen 300mg iv dripping
experimental group	Ibuprofen	the combination of acetaminophen 1g and ibuprofen 300mg iv dripping

Primary Outcome Measures

Name	Time	Method
postoperative pain	during 30 minutes after surgery	the maximal postoperative pain severity using pain scale (0=no pain; 10=the worst pain)

Trial Locations

Locations (1)

Seoul St.Mary's Hospital; 🇰🇷 Seoul, Seocho-gu, Korea, Republic of