Effect of erythropoietin on outcome of severe brain injured patients

Not Applicable

Conditions: Traumatic brain injury.
Diffuse brain injury , Focal brain injury
S06.2 , S0

Registration Number: IRCT2013072414138N1

Lead Sponsor: Kashan University of Medical Sciences, Deputy of Research

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 60

Inclusion Criteria

severe brain injury (Glasgow coma scale less than or equal to 8) with a single brain lesion volume less than 30 ml or those who have diffuse axonal injury; age between 15-65 years; no need for surgical operation; possibility of following up during the study period; having informed consent from first-degree relatives.
Exclusion criteria: mild to moderate brain injury; patients with massive brain lesions( more than 30 ml volume); age less than 15 and over 65; surgical operation; cases with neoplasia in skull; multiple trauma; myeloproliferative diseases; polycythemia; sensitivity to erythropoietin; hyperkalemia; creatinine more than 3 mg/dl; all patients that their following- up is not guaranteed during the study; participating other trials; history of deep vein thrombosis; pregnancy; clinical brain death (without brain stem reflexes).

Exclusion Criteria

Not provided

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Patient's outcome. Timepoint: 3 and 6 month after intervention. Method of measurement: Based on Glasgow coma scale.;Lesion size. Timepoint: Before, 15 and 30 days after intervention. Method of measurement: Based on CT-Scan and radiologist's report.

Secondary Outcome Measures