Clinical and Economic Impact of Interventions by a Clinical Pharmacist on Antibiotic Use on Surgical Wards

Not Applicable

Completed

• Conditions: Bacterial Infections
• Interventions: Behavioral: pharmaceutical consulting

• Registration Number: NCT00431483
• Lead Sponsor: Ludwig-Maximilians - University of Munich

Brief Summary

The purpose of this study is to establish the impact of a pharmacist's recommendations regarding choice, dosing and duration of antibiotic therapy on quality and cost of antibiotic treatment on surgical wards.

Detailed Description

Inappropriate or incorrect use of antibacterials exerts selection pressure on pathogens potentiating emergence of resistance, puts patients at risk for unnecessary adverse drug reactions and potentially prolongs the length of stay in hospital thus increasing healthcare costs.

In an effort to improve the quality of antibiotic drug therapy on surgical wards of a large university hospital, specific consulting by a clinical pharmacist was established.

The objective of this study is to assess the impact of pharmaceutical consulting on the quality and costs of antibiotic use in surgical wards.

Comparison:

Within a control period the current pattern of antibiotic use is monitored. During the intervention period, the impact of the interventions made by the clinical pharmacist on antibiotic use is examined. One ward serves as a parallel control group; no intervention is being made on this ward throughout this study.

Study Timeline

• Study Start: 2007-02
• Study First Submitted: 2007-02-01
• Study First Submitted QC: 2007-02-01
• Study First Posted: 2007-02-05
• Primary Completion: 2008-02
• Study Completion: 2008-02
• Status Verified: 2013-09
• Last Update Submitted: 2013-09-25
• Last Update Posted: 2013-09-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 779

Inclusion Criteria

• female and male patients receiving antibiotics for a proven or suspected infection on designated surgical wards

Exclusion Criteria

• patients under 18
• patients unable or unwilling to consent to their data being evaluated
• patients receiving antibiotics perioperatively as prophylaxis
• patients receiving antibiotics for less than 48hrs

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Pharmaceutical counseling	pharmaceutical consulting	-

Primary Outcome Measures

Name	Time	Method
overall duration of antibiotic therapy during study period	Feb 2008

Secondary Outcome Measures

Name	Time	Method
iv to oral switch	Feb 2008	number of courses of iv antibiotics switched to oral antibiotics; duration of iv treatment
compliance of treatment with hospital formulary for antibiotic therapy	Feb 2008
cost of antibiotic therapy	Feb 2008
number and duration of therapy with antibiotics with redundant spectra	Feb 2008

Trial Locations

Locations (1)

Luwig Maximilians University - Klinikum Grosshadern; 🇩🇪 Munich, Bavaria, Germany