Modulation of cardiac autonomic control by resistance training in Type 2 Diabetes Mellitus

Cardiac autonomic neuropathy (CAN) is a common yet overlooked complication of type 2 diabetes mellitus (T2DM). It has been found to be associated with various cardiovascular diseases and mortality but still there is lack of specific interventions targeting diabetic CAN. Exercise training has been shown be an effective adjunct therapy to modulate impaired cardiac autonomic control of T2DM patients, however, there is so far no study on the effect of resistance training (RT) on cardiac autonomic control of T2DM patients. Although neuromuscular benefits of RT are well established in scientific literature, there is no consensus on its cardiac autonomic effects. Therefore, the present study is a randomised, signle blinded, parallel group trial to ascertain the effects of RT on the cardiac autonomic control of T2DM patients. Apart from cardiac autonomic control, this study intends to investigate the effect of RT on biomarkers of systemic inflammation & endothelial function, glycemic & metabolic profile, muscle function, vascular function, blood lactate, body composition, quality of life, well-being and sleep quality of T2DM patients. This study is to be conducted at Jamia Millia Islamia. The patients will be recruited M A Ansari Health Centre, Jamia Millia Islamia. If came out with positive results, this study has the potential to help clinicians working with T2DM patients in formulating exercise protocols for optimal benefits.