The olfactory function in nasopharyngeal cancer patients after radiotherapy: a prospective cohort study
Recruiting
- Conditions
- The objective and subjective olfactory function changes in patients with nasopharyngeal cancer treated with advanced radiation therapyolfactory function, olfaction, cranial nerve function, radiation therapy, radiotherapy, head and neck cancer, survivorship, radiation side effect, quality of life
- Registration Number
- TCTR20230601007
- Lead Sponsor
- Ratchadapisek Research Funds
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 41
Inclusion Criteria
1. Patients with newly diagnosed stage I to IVA biopsy proven nasopharyngeal cancer who are planned to receive definitive radiotherapy with or without systemic therapy, 2. Normal pre treatment olfactory function defined by more than or equal to 14 from 16 points of the Thai modification version of Sniffin sticks test, 3. Age higher than 18 years old and consent to the study
Exclusion Criteria
1. Tumor involvement at the olfactory groove, 2. History of surgery involving nasal cavity area except for incisional or excisional biopsy, 3. Prior history of radiotherapy at head and neck area or systemic therapy, 4. Evidence of distant metastasis
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Temporal change in olfactory function at pre-induction chemotherapy if any, pre-radiation, last week of radiation, 3 months and 6 months after radiation Olfactory identification assessment, visual analog scale, quality of life questionnaires
- Secondary Outcome Measures
Name Time Method Radiation dose relating to olfactory dysfunction At last week of radiation, 3 months and 6 months after radiation dose-volume parameters to the olfactory region,Incidence of rhinosinusitis after radiation At pre-induction chemotherapy if any, pre-radiation, last week of radiation, 3 months and 6 months after radiation Nasal endoscopy