Left Ventricular Diastolic Dysfunction as a Risk Factor for Interstitial Lung Edema in Septic Patients on the Intensive Care Unit
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Sepsis
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
- Enrollment
- 83
- Locations
- 1
- Primary Endpoint
- Diastolic Dysfunction
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
Sepsis is one of the most challenging conditions with an exceptionally high mortality rate. Diastolic Dysfunction is common in septic patients and has been found to be associated with mortality. However, the reasons for this remain unclear. Therefore, the goal of this study is to investigate diastolic dysfunction in septic patients on the intensive care unit. Special attention is paid to the presence of lung edema and general edema as a potential link between diastolic dysfunction and elevated mortality in septic patients. During the septic phase daily ultrasound examinations of heart and lung will be performed as to monitor diastolic function and lung edema.
Investigators
Ursula Kahl
Dr. med.
Universitätsklinikum Hamburg-Eppendorf
Eligibility Criteria
Inclusion Criteria
- •Patients on the intensive care unit diagnosed with SIRS (systemic inflammatory response syndrome) or Sepsis.
Exclusion Criteria
- •Patients with hemodynamically relevant cardiac defects.
- •Patients with mitral valve replacement.
- •Patients with pericardial effusion.
- •Patients with atrial fibrillation.
- •Patients with pacemaker therapy.
- •Patients with BMI \> 35 kg/m
- •Patients with poor examination conditions for ultrasound.
Outcomes
Primary Outcomes
Diastolic Dysfunction
Time Frame: While in septic condition, up to 10 days maximum.
Diastolic Dysfunction specified by echocardiographic doppler derived mitral inflow pattern and tissue doppler derived diastolic mitral annular velocities (E/E').
Pulmonary Edema
Time Frame: While in septic condition, up to 10 days maximum.
Pulmonary edema specified by B line ultrasound score (Lung ultrasound protocol for the assessment of pulmonary fluid status according to Enghardt et al. 2015).