Left Ventricular Diastolic Function During Anesthesia Induction

Completed

• Conditions: Left Ventricular Diastolic Dysfunction
• Interventions: Drug: Sevoflurane; Drug: Propofol

• Registration Number: NCT03522194
• Lead Sponsor: Universitätsklinikum Hamburg-Eppendorf

Brief Summary

Diastolic dysfunction is an important cause of hemodynamic instability in the perioperative field.Therefore this study aims to investigate the influence of existing diastolic dysfunction or deterioration of diastolic function on hemodynamic stability during induction of anesthesia and postoperative complications. The impact of different anesthetics on diastolic function is investigated.

Detailed Description

In this prospective observational study two cohorts of patients with different anesthesia regimes are investigated. Anesthesia is maintained with sevoflurane or propofol. Before induction of anesthesia a transthoracic echocardiography is performed to examine systolic and diastolic function. Immediately after induction, during maintenance and after completion of anesthesia any changes of diastolic function are examined with transthoracic echocardiography. All anesthetic medications, fluids, vasoactive medications and catecholamines are registered.

Study Timeline

• Study Start: 2017-04-01
• Study First Submitted: 2018-04-30
• Study First Submitted QC: 2018-04-30
• Study First Posted: 2018-05-11
• Primary Completion: 2018-09-27
• Study Completion: 2018-09-27
• Status Verified: 2019-03
• Last Update Submitted: 2019-03-10
• Last Update Posted: 2019-03-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• Patients older than 60 years scheduled for general anesthesia

Exclusion Criteria

• Mitral regurgitation or stenosis > I°
• Sp. mitral valve repair or replacement
• Pericardial effusion
• Atrial fibrillation/flutter
• Patients with pacemaker
• BMI > 35 kg/m2

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Sevoflurane	Sevoflurane	Anesthesia maintenance
Propofol	Propofol	Anesthesia maintenance

Primary Outcome Measures

Name	Time	Method
Norepinephrine	30 minutes after induction of anesthesia	Cumulative dose of norepinephrine (adjusted for body weight) during the first 30 minutes after induction of anesthesia

Secondary Outcome Measures

Name	Time	Method
e'	Directly after induction of anesthesia	Change of the echocardiographic tissue doppler parameter e' after induction of anesthesia
E / e'	Directly after induction of anesthesia	Change of the echocardiographic index of transmitral flow and tissue doppler after induction of anesthesia

Trial Locations

Locations (1)

Universitätsklinikum Hamburg-Eppendorf; 🇩🇪 Hamburg, Germany