Influence of Left Ventricular Diastolic Function on Hemodynamic Stability During Anesthesia Induction and on Postoperative Complications
Overview
- Phase
- N/A
- Intervention
- Sevoflurane
- Conditions
- Left Ventricular Diastolic Dysfunction
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
- Enrollment
- 200
- Locations
- 1
- Primary Endpoint
- Norepinephrine
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
Diastolic dysfunction is an important cause of hemodynamic instability in the perioperative field.Therefore this study aims to investigate the influence of existing diastolic dysfunction or deterioration of diastolic function on hemodynamic stability during induction of anesthesia and postoperative complications. The impact of different anesthetics on diastolic function is investigated.
Detailed Description
In this prospective observational study two cohorts of patients with different anesthesia regimes are investigated. Anesthesia is maintained with sevoflurane or propofol. Before induction of anesthesia a transthoracic echocardiography is performed to examine systolic and diastolic function. Immediately after induction, during maintenance and after completion of anesthesia any changes of diastolic function are examined with transthoracic echocardiography. All anesthetic medications, fluids, vasoactive medications and catecholamines are registered.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients older than 60 years scheduled for general anesthesia
Exclusion Criteria
- •Mitral regurgitation or stenosis \> I°
- •Sp. mitral valve repair or replacement
- •Pericardial effusion
- •Atrial fibrillation/flutter
- •Patients with pacemaker
- •BMI \> 35 kg/m2
Arms & Interventions
Sevoflurane
Anesthesia maintenance
Intervention: Sevoflurane
Propofol
Anesthesia maintenance
Intervention: Propofol
Outcomes
Primary Outcomes
Norepinephrine
Time Frame: 30 minutes after induction of anesthesia
Cumulative dose of norepinephrine (adjusted for body weight) during the first 30 minutes after induction of anesthesia
Secondary Outcomes
- e'(Directly after induction of anesthesia)
- E / e'(Directly after induction of anesthesia)