Effect of awake proning in patients with COVID-19 related respiratory failure
Phase 3
- Conditions
- Health Condition 1: B972- Coronavirus as the cause of diseases classified elsewhereHealth Condition 2: J128- Other viral pneumonia
- Registration Number
- CTRI/2020/07/026349
- Lead Sponsor
- Anant Mohan
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
a)All adults > 18 years of age with acute hypoxemic respiratory failure with room air saturation < 93% or PaO2/ FiO2 <=300 AND
b)COVID -19 positive by RT- PCR or COVID-19 suspected as the most probable clinco-radiological diagnosis of acute respiratory failure
Exclusion Criteria
1)Age <18 yrs or >70 yrs;
2)Severe ARDS P/F < 100mmHg
3)PaCO2 >50 mm Hg;
4)Glasgow Coma Scale <11;
5)Unable to spontaneously clear secretions from the airways
6)Requirement of emergency intubation for cardiopulmonary resuscitation, respiratory arrest, severe hemodynamic instability
7)Refusal to receive NPPV/ HFNC/ NRBM
8)Unable to cooperate with NPPV/ HFNC/ NRBM application
9)Pregnancy
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To study the rate of invasive mechanical ventilation in patients treated with awake proning along with non-invasive methods of oxygen delivery in patients of COVID -19 positive acute hypoxemic respiratory failureTimepoint: till discharge or intubation
- Secondary Outcome Measures
Name Time Method 1.To study the improvement in oxygenation parameters (SO2, SO2/ FiO2, PaO2/ FiO2 ratio and ROX index) in patients undergoing prone positioning <br/ ><br>2.Duration of hospital stay <br/ ><br>Timepoint: till discharge or intubation