Awake Prone Positioning for COVID-19 Acute Hypoxaemic Respiratory Failure

Completed

• Conditions: Survival, Prosthesis; Oxygen Deficiency
• Interventions: Other: Prone position

• Registration Number: NCT05866289
• Lead Sponsor: Mohammed VI University Hospital

Brief Summary

The objective of our study is to evaluate the effectiveness of prone position in preventing intubation or death in spontaneously ventilated patients with COVID-19 with acute respiratory failure.

Detailed Description

The COVID-19 pandemic has challenged the management of hypoxemic respiratory failure as limited ICU capacity is strained by a new high-mortality disease and large numbers of patients requiring prolonged periods of hospitalization, as well as respiratory support equipment such as ventilators and intensive care unit (ICU) beds.

If early and prolonged prone positioning (DV) reduces mortality in invasively ventilated patients with acute respiratory distress syndrome (ARDS), its role in conscious patients (DV vigil) remains a subject of debate and research.

This is a retrospective, monocentric, descriptive and analytical cohort conducted over a period of 22 months from March 2020 to December 2021 and involving 1069 patients hospitalized in the intensive care unit of the CHU Mohammed VI of Oujda for the management of acute respiratory failure caused by COVID-19.

Study Timeline

• Study Start: 2020-03-01
• Primary Completion: 2021-12-28
• Study Completion: 2021-12-30
• Study First Submitted: 2023-03-27
• Status Verified: 2023-05
• Study First Submitted QC: 2023-05-17
• Last Update Submitted: 2023-05-17
• Study First Posted: 2023-05-19
• Last Update Posted: 2023-05-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1069

Inclusion Criteria

• all patients (1069 patients) with ARDS due to SARS-cov2, confirmed by nasopharyngeal swab, who were hospitalized in the COVID-19 ICU from March 1, 2020 to December 31, 2021

Exclusion Criteria

• Patients with negative CRP
• Younger than 18 years of age
• Patients who died or intubated on the day of admission
• Patients presented a contraindication

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Includes 681 patients who were placed in prone position	Prone position	-

Primary Outcome Measures

Name	Time	Method
Evaluate the effectiveness of awake prone position in preventing intubation or death in spontaneously ventilated patients with COVID-19 with acute respiratory failure.	22 months	Evaluate the effectiveness of awake prone position in preventing intubation or death in spontaneously ventilated patients with COVID-19 with acute respiratory failure.

Secondary Outcome Measures

Name	Time	Method
length of stay in intensive care unit, length of time from hospitalization to death, length of time from hospitalization to intubation.	22 months	length of stay in intensive care unit, length of time from hospitalization to death, length of time from hospitalization to intubation.

Trial Locations

Locations (1)

Amine Elmouhib; 🇲🇦 Oujda, Morocco