Regulation of L-Arginine Und Its Derivatives of Asymmetrical and Symmetrical Dimethylarginine and L-NG Monomethylarginine (ADMA/SDMA/L-NMMA) in Acute Kidney Injury and Correlation to Cardiac, Renal and Vascular Function and Mortality
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- Difference in serum SDMA level between acute kidney injury and renal recovery
研究概览
简要总结
The purpose of the study is to determine the association between acute kidney injury and serum levels symmetrical and asymmetrical dimethylarginine (SDMA/ADMA) and their assumptive influence on mortality, renal function and on arterial stiffness.
详细描述
Acute kidney injury (AKI) is a frequent complication with severe implications deteriorating overall prognosis. Nitric oxide (NO)-signal transduction plays an important role in mediating renal damage. NO is produced by NO-synthase (NOS) with L-arginine as its substrate. Endogenous L-Arginine derivatives, asymmetric and symmetric dimethylarginines (ADMA/SDMA), inhibit NO-production directly (AMDA) by blocking NOS activity or indirectly (SDMA) by blocking cellular L-Arginine uptake.
It is well known that SDMA and ADMA are markers of renal function (SDMA) and cardiovascular risk (ADMA/SDMA) in patients with chronic kidney disease (CKD). Moreover, ADMA and SDMA possibly even trigger cardiovascular risk in patients with CKD. However, there is only little information about the regulation and the influence of ADMA/SDMA in acute kidney injury.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •acute kidney injury according to the definition of AKIN (Acute Kidney Injury Network)
- •no started renal replacement therapy (e.g. dialysis)
排除标准
- •dialysis or continuous venovenous hemofiltration before recruitment
- •no recovery from kidney injury according to the definition of AKIN (Acute Kidney Injury Network)
- •palliative care
- •life expectancy is severely limited (< six months) due to preexisting malignancy or other disease
结局指标
主要结局
Difference in serum SDMA level between acute kidney injury and renal recovery
时间窗: participants will be followed from the time of recruitment to the end of hospital stay, an expected average of 2 weeks
Difference in serum ADMA level between acute kidney injury and renal recovery
时间窗: participants will be followed from the time of recruitment to the end of hospital stay, an expected average of 2 weeks
次要结局
- Associations between ADMA/SDMA serum level and parameters of arterial stiffness(participants will be followed from the time of recruitment to the end of hospital stay, an expected average of 2 weeks)
- Associations between ADMA/SDMA serum level and parameters of renal function(participants will be followed from the time of recruitment to the end of hospital stay, an expected average of 2 weeks)
- Associations between ADMA/SDMA serum level and all cause mortality(participants will be followed from the time of recruitment to the end of hospital stay, an expected average of 2 weeks)