Effect of Childhood Radioiodine Therapy on Salivary Function
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- Responses to Dry Mouth Questionnaire
研究概览
简要总结
Radioiodine (I-131) therapy for thyroid disease is known to decrease salivary function in adult patients. The impact of pediatric I-131 exposure on salivary function is unknown. The investigators goals are to answer this question by measuring salivary gland function before and after I-131 administration in children who receive radioiodine therapy at our hospital for thyroid disease.
详细描述
Radioiodine (I-131) therapy for thyroid disease is known to decrease salivary function in adult patients. The impact of pediatric I-131 exposure on salivary function is unknown. The investigators goals are to answer this question by measuring salivary gland function before and after I-131 administration in children who receive radioiodine therapy at our hospital for thyroid disease. We will use a Modified Shirmer Test to measure saliva production and a questionnaire to evaluation symptoms of xerostomia.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 3 Years 至 55 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who have been treated with radioiodine therapy
- •Patients who have never received radioiodine therapy (negative control group)
排除标准
- •Non-English speaking subjects will be excluded due to our lack of translation support resources at this time. Of note, participation in our study cannot benefit participants in any way.
结局指标
主要结局
Responses to Dry Mouth Questionnaire
时间窗: At time of visit up to 4 months thereafter.
Patient questionnaire/survey
Salivary function (MST value)
时间窗: 0 to 50 years after radioiodine treatment
sterile paper strip is used to measure saliva production (noninvasive testing)
次要结局
- Caries history (number of caries noted in dental records)(1 year before radioiodine administration to 4 months after study visit.)
研究者
Ari Wassner
Director, Thyroid Program, Division of Endocrinology
Boston Children's Hospital