Relation of C-reactive Protein/ Albumin Ratio and Coagulation Profile in Acute Myeloid Leukemia Patients

Not yet recruiting

• Conditions: AML

• Registration Number: NCT06714071
• Lead Sponsor: Assiut University

Brief Summary

The investigators will investigate the relation between CAR and coagulation profile in newly diagnosed AMl patients

Detailed Description

Acute myeloid leukaemia (AML) is an aggressive haematological malignancy with a high degree of heterogeneity. It has long been recognized that systemic inflammation is associated with tumorigenesis it revealed that elevated C-reactive protein levels were associated with worse survival outcomes in patients with various types of cancer, including hematologic malignancies. Serum albumin is a measure of an individual's nutritional status. Systemic inflammation can reduce serum albumin concentrations by increasing capillary permeability . The ratio of CRP to albumin (CAR) is a useful score based on inflammation and nutrition, reflecting not only systemic inflammation status but also nutritional status. The Glasgow prognostic score (GPS) and modified GPS (mGPS), determined by the serum CRP and albumin levels, have been proposed as prognostic indicators for AML patients. However, the clinical correlations of CAR and its prognostic value in AML patients have not yet been clarified. Abnormalities of hemostasis can occur in leukemia in the form of disseminated intravascular coagulation(DIC), coagulation protein defect and primary fibrinolysis . Clinically, Types of acute myeloid leukemia like acute promyelocyticleukemia has a high frequency of haemorrhage due to disseminated intravascular coagulation (DIC), which contributes to the high mortality rate of this disease . Therefore, the investigators will investigate CAR its relation with inflammatory response and coagulation profile levels in newly diagnosed acute myeloid leukemia and after 3 month follow up to compare their level and the relation between .

Study Timeline

• Study First Submitted: 2024-11-08
• Study First Submitted QC: 2024-12-02
• Study First Posted: 2024-12-03
• Status Verified: 2025-01
• Last Update Submitted: 2025-01-27
• Last Update Posted: 2025-01-28
• Study Start: 2025-04
• Primary Completion: 2027-03-01
• Study Completion: 2027-05-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• all cases newly diagnosed with acute myeloid leukemiain assuit university hospital

Exclusion Criteria

1. cases with chronic myeloid leukemia
2. cases with acute lymphoblasticleukemia

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Correlation between C- reactive protein and coagulation profile in AML patients	Study complete an average 2 years	the investigators will investigate the correlation between CAR and coagulation profile in newly diagnosed AMl patients by measure crp and coagulation profile in newly diagnosed patient and up to 3 month follow up

Trial Locations

Locations (1)

Assiut University; 🇪🇬 Assiut, Egypt