Short-term Changes on C-Reactive Protein (CRP) Levels After Non-surgical Periodontal Treatment

Not Applicable

Completed

• Conditions: Chronic Periodontitis; Atherosclerotic Cardiovascular Disease
• Interventions: Procedure: Non-surgical periodontal treatment

• Registration Number: NCT01433744
• Lead Sponsor: State University of Maringá

Brief Summary

The hypotheses tested were that levels of C-Reactive Protein (CRP) would be higher in patients with chronic periodontitis in comparison with those without periodontal disease and that the non-surgical periodontal treatment would decrease levels of CRP in patients with chronic periodontitis.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-01
• Primary Completion: 2011-07
• Study Completion: 2011-07
• Status Verified: 2011-09
• Study First Submitted: 2011-09-12
• Study First Submitted QC: 2011-09-13
• Last Update Submitted: 2011-09-13
• Study First Posted: 2011-09-14
• Last Update Posted: 2011-09-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 44

Inclusion Criteria

Patients should have ≥ 20 teeth present; (ii) absence of oral soft tissue lesions; (iii) have ≤ 3 carious lesions in all teeth. In addition, to be included in the Test group the subject had to present chronic periodontitis (involvement of at least 5 teeth with at least one site presenting probing depth (PD) ≥ 5 mm and clinical attachment loss (CAL) ≥ 3 mm) while to be included in the Control group the patient had to exhibit periodontal healthy (bleeding on probing (BOP) < 30% of the sites and absence of any PD > 4mm associated with BOP).

Exclusion Criteria

(i) periodontal disease treatment in the previous six months; (ii) aged less than 35 years; (iii) systemic conditions such as history of CVD or any other chronic or immunologic diseases and the use of related drugs in the previous six months; (iv) smokers or former smokers; (v) pregnant or lactating women; (vi) hypertension (>140 systolic and > 90 diastolic mmHg); (vii) obesity (Body Mass Index (BMI) ≥ 30 kg/m²); (viii) levels of HDL-cholesterol > 35.0 mg/dL (ix) levels of LDL-cholesterol < 160.0 mg/dL (x)levels of triglycerides < 400.0 mg/dL and (xi) levels of glucose levels < 100 mg/dL.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Chronic periodontal disease	Non-surgical periodontal treatment	C-reactive protein levels assesments and periodontal treatment

Primary Outcome Measures

Name	Time	Method
C-Reactive Protein levels	Baseline and 60 days after treatment

Secondary Outcome Measures

Name	Time	Method
The effect of non-surgical periodontal treatment on patients with chronic periodontitis	Baseline and re-evaluation 60 days after the end of treatment

Trial Locations

Locations (1)

Departament of Dentistry of State University of Maringá; 🇧🇷 Maringá, Paraná, Brazil