Consequences of a Brain Lesion or of Migraine on Auditory Processing: Attention, Memory and Emotion
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 262
- 试验地点
- 4
- 主要终点
- Percentages of correct responses in Neuropsychological tests
研究概览
简要总结
The project studies auditory processing after brain damage (in temporal and/or frontal areas) and in migraine. The auditory processes investigated are attention, short-term memory, sound-induced emotions. To characterize auditory deficits after brain damage or in migraine, neuropsychological assessments are combined with neurophysiological markers (Electro-encephalography: EEG, Magneto-encephalography: MEG, Magnetic Resonance Imaging: MRI).
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age from 18 to 80
- •MEG/MRI compatibility
- •Motivation to participate efficiently in the study
- •No severe hearing loss
- •Informed consent to participate in the study
- •Affiliation to social security
- •For brain-damaged patients : no need for medical assistance; focal temporal and/or frontal lesion; no major cognitive impairment; ability to understand and apply the instructions for neuropsychological testing; testing at least one-month after the event resulting in brain damage; absence of neurological and psychiatric disorders besides the lesion
- •For migraine patients: no need for medical assistance; migraine diagnosis; no major cognitive impairment; ability to understand and apply the instructions for neuropsychological testing; absence of neurological and psychiatric disorders besides the migraine
- •Healthy participants: absence of neurological and psychiatric disorders
排除标准
- •Age below 18 or above 80
- •MRI scanning not possible: artificial cardiac pacemaker, insulin pump, metallic prosthesis, intra-cerebral clip, claustrophobia
- •MEG acquisition not possible: large heads, neurostimulator, metal in the head or the body.
- •Pregnant or breast-feeding women
研究组 & 干预措施
Migraine patients
干预措施: Neuropsychological tests (Other)
Migraine patients
干预措施: Neurophysiological tests (Other)
Brain-damaged patients
干预措施: Neuropsychological tests (Other)
Brain-damaged patients
干预措施: Neurophysiological tests (Other)
Control participants
干预措施: Neuropsychological tests (Other)
Control participants
干预措施: Neurophysiological tests (Other)
结局指标
主要结局
Percentages of correct responses in Neuropsychological tests
时间窗: up to 2 months
reaction times in Neuropsychological tests
时间窗: up to 2 months
次要结局
- Event-Related Fields (MEG) in Neurophysiological tests(up to 2 months)
- Event-Related Potentials (EEG) in Neurophysiological tests(up to 2 months)