In vitro coagulation dynamics of conformational changes in ADAMTS13

Completed

• Conditions: acute traumatic coagulopathy; 10064477; Trauma-induced coagulopathy

• Registration Number: NL-OMON50123
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 24

Inclusion Criteria

Healthy male volunteers (age: 18-35 years)

Exclusion Criteria

- Participation in a scientific intervention study in the last 3 months
- No informed consent
- History of coagulation disorders
- Active use of prescription medication
- Use of anticoagulant medication, including aspirin
- History of liver disease
- History of chronic transmittable disease
- History of alcohol, smoking or drug abuse
- History of alcohol/drug use in past 24 hours

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>In vitro: whether open conformation of ADAMTS13 is associated with<br /><br>hyperfibrino(geno)lysis determined by ROTEM, coagulation proteins measurements,<br /><br>and/or other whole blood or plasmatic coagulation tests.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary outcomes will be related to factors contributing to open conformation<br /><br>ADAMTS13 and the effects of ADAMTS13 and/or hyperfibrino(geno)lysis on<br /><br>coagulation components such as platelets. </p><br>