Diagnosis and elucidation of small-fiber dysfunction using electrophysiological technique
Not Applicable
- Conditions
- Familial amyloid polyneuropathy
- Registration Number
- JPRN-UMIN000027045
- Lead Sponsor
- Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine
- Brief Summary
Pain detection threshold using intraepidermal electrical stimulation (IES) and cooling detection threshold using quantitative sensory testing (QST) were positively correlated. Amplitude of evoked potentials (EPs) following electrical stimulation using IES was negatively correlated with pain and cooling detection thresholds. Sensory thresholds and amplitude of EPs were deteriorated with length-dependent pattern in patients with familial amyloid polyneuropathy. These results support a notion that IES is a useful clinical tool for evaluating small-fiber dysfunction.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
Not provided
Exclusion Criteria
Patients or healthy subjects with other neuropathy
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method