Smoking Cessation in Patients After Coronary Angiography

Completed

• Conditions: Coronary Artery Disease

• Registration Number: NCT04784702
• Lead Sponsor: Centre of Postgraduate Medical Education

Brief Summary

OBJECTIVES The goal of this study is to evaluate the self-achieved smoking cessation supported with cytisine smoking cessation and its' on platelet aggregation and prothrombotic state in patients after coronary angiography and PCI.

BACKGROUND Cigarette smoking is a major risk factor of coronary artery disease (CAD). Smoking cessation is one of the most cost-effective intervention in lifestyle. Self-reported rates of smoking cessation are reasonably low. Cytisine is promising drug in support of smoking cessation. Smoking affects various components leading to arterial thrombosis, and the effect of smoking cessation on prothrombotic state and platelet aggregation is still under investigation GOAL To assess rates of smoking cessation in patients after coronary angiography and PCI and factors influencing success in smoking cessation To assess feasibility, safety and efficacy of cytisine in smoking patients To assess effect of smoking cessation on platelet aggregation in patients treated with clopidogrel and on prothrombotic state.

METHODS A prospective nonrandomized observational study of patients after coronary angiography.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-08-05
• Primary Completion: 2016-12-31
• Study Completion: 2017-01-30
• Study First Submitted: 2021-02-25
• Status Verified: 2021-03
• Study First Submitted QC: 2021-03-03
• Last Update Submitted: 2021-03-03
• Study First Posted: 2021-03-05
• Last Update Posted: 2021-03-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 122

Inclusion Criteria

• Patients after coronary angiography or PCI,
• Aged 18 years or older,
• Smoking at least 10 cigarettes a day

Exclusion Criteria

• Pregnancy

Criteria may vary in substudies

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Platelet aggregation in patient treated with clopidogrel after smoking cessation	30-days	Platelet reactivity measured with PRU

Secondary Outcome Measures

Name	Time	Method
Prothrombotic state	30-days	Various biomarkers
Thrombomodulin	30-days	Changes of thrombomodulin concentration
PAI-1	30-days	Changes of PAI-1 concentration
Thrombin potential	30-day	Assessment of endogenous thrombin potential
P-selectin	30-days	Changes of p-selectin concentration
Thromboglobulin	30-days	Changes of thromboglobulin concentration
PF-4	30-days	Changes of PF-4 concentration
Cotinine	30-days	Changes in concentration of cotinine