Smoking Cessation in Patients After Coronary Angiography - Self-achieved and Supported With Cytisine and Its' Effect on Platelet Aggregation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 122
- 主要终点
- Platelet aggregation in patient treated with clopidogrel after smoking cessation
研究概览
简要总结
OBJECTIVES The goal of this study is to evaluate the self-achieved smoking cessation supported with cytisine smoking cessation and its' on platelet aggregation and prothrombotic state in patients after coronary angiography and PCI.
BACKGROUND Cigarette smoking is a major risk factor of coronary artery disease (CAD). Smoking cessation is one of the most cost-effective intervention in lifestyle. Self-reported rates of smoking cessation are reasonably low. Cytisine is promising drug in support of smoking cessation. Smoking affects various components leading to arterial thrombosis, and the effect of smoking cessation on prothrombotic state and platelet aggregation is still under investigation GOAL To assess rates of smoking cessation in patients after coronary angiography and PCI and factors influencing success in smoking cessation To assess feasibility, safety and efficacy of cytisine in smoking patients To assess effect of smoking cessation on platelet aggregation in patients treated with clopidogrel and on prothrombotic state.
METHODS A prospective nonrandomized observational study of patients after coronary angiography.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients after coronary angiography or PCI,
- •Aged 18 years or older,
- •Smoking at least 10 cigarettes a day
排除标准
- •Pregnancy
- •Criteria may vary in substudies
结局指标
主要结局
Platelet aggregation in patient treated with clopidogrel after smoking cessation
时间窗: 30-days
Platelet reactivity measured with PRU
次要结局
- Cotinine(30-days)
- Prothrombotic state(30-days)
- Thrombomodulin(30-days)
- PAI-1(30-days)
- Thrombin potential(30-day)
- P-selectin(30-days)
- Thromboglobulin(30-days)
- PF-4(30-days)
研究者
Bogumil Ramotowski
MD, PhD, Adjunct, Director of the Programme
Centre of Postgraduate Medical Education