NCT07120958Enrolling By Invitation不适用
What Impact Does Uterine Immunity Have on the Success of Euploid Thawed Embryos?
Momo Fertilife1 个研究点 分布在 1 个国家目标入组 30 人开始时间: 2025年5月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Characterise the molecular immunologic mechanism underlying embryo implantation
研究概览
简要总结
Evaluation of uterine immunity, histological picture, and endometrial microbiome for embryo implantation
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 42 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Female patients aged >18 and <43 years at the time of embryo transfer.
- •Transfer of cryopreserved embryos diagnosed as euploid through preimplantation genetic testing for aneuploidy (PGT-A).
- •Embryo transfer performed at the blastocyst stage.
排除标准
- •Patients with an intrauterine device (IUD) in situ within the three months prior to study enrollment.
- •Presence of autoimmune diseases and/or ongoing treatment with corticosteroids.
- •Structural or pathological abnormalities of the uterine cavity, including but not limited to polyps, intramural myomas measuring 2-4 cm, submucosal fibroids, uterine septum, or hydrosalpinx, identified during study participation. Patients with a history of these conditions may be included if the pathology has been resolved prior to the initiation of any study-related procedures or sample collection.
- •Presence of severe or uncontrolled fungal or viral infections which, in the opinion of the principal investigator, may compromise the patient's ability to participate or affect the integrity of study outcomes.
- •Any medical condition or illness that is unstable, poses a potential risk to patient safety, or may interfere with adherence to the study protocol.
- •Patients lacking a confirmed preimplantation genetic diagnosis of euploidy.
- •Patients with a clinical diagnosis of endometriosis or adenomyosis.
结局指标
主要结局
Characterise the molecular immunologic mechanism underlying embryo implantation
时间窗: from enrollment to the pregnancy test (12 days after embryo transfer)
The main objective of this research is to characterise the molecular immunologic mechanism underlying embryo implantation. These outcomes will be assessed regarding the percentage of expressivity of some interleukins in pregnant couples and those who are not
次要结局
- to study the possible correlations of the expression of the interleukins involved in the implantation process of the embryo(The endometrial biopsy on which the interleukin dosage will be done, will be taken one month before the embryo transfer)
研究者
Daniele Ferri
IVF Lab Manager
Momo Fertilife
研究点 (1)
Loading locations...
相似试验
招募中
不适用
From Fetal-maternal Interface Immune Tolerance to Endometrial Cancer Immune Escape: Potential Targets for ImmunotherapyEndometrial CancerNCT06273878Regina Elena Cancer Institute80
尚未招募
不适用
Impact of Uterine Immune Profiling and Personalized Treatments in Patients Receiving a Single Blastocyst: a Matched Controlled StudySuccess Rate of Assisted Reproductive TherapySingle Embryo TransferPregnancy OutcomesImmunological ToleranceImmune SystemInfertilityNCT06503952Matricelab Innove340
招募中
不适用
Effect of intrauterine microbial colonization on reproductive outcome in infertile women undergoing assisted reproductive technologyInfertilityJPRN-UMIN000023333Kyoto Prefectural University of Medicine100
已完成
不适用
Chronic Endometritis and IVFChronic Endometritisin Vitro FertilizationNCT02646930Duke University57
已完成
不适用
Uterine Microbiome in Women With Repeated Implantation Failure and Normal Fertile WomenRepeated Implantation FailureNormal FertileNCT03405883University Hospital, Ghent13