Personalized Computerized Training Program for Cognitive Dysfunction After COVID-19

Not Applicable

Completed

• Conditions: Post-Acute COVID-19; Long COVID
• Interventions: Device: CogniFit's CCT Post COVID-19

• Registration Number: NCT05571852
• Lead Sponsor: Universidad Antonio de Nebrija

Brief Summary

This before-and-after study aims to evaluate the usefulness and efficacy of a personalized computerized cognitive training (CCT) to improve cognitive function among people with post-acute sequelae of COVID-19 (PASC).

Detailed Description

Through an online platform created for the study, adults who self-reported cognitive impairment more than 3 months after receiving a COVID-19 diagnosis will be enlisted and their cognitive status will be assessed using a commercially available test. After determining their level of general cognitive dysfunction, those who qualify and meet the inclusion criteria will be invited to use a customized computerized cognitive training (CCT) program at home and to complete as many daily training sessions as they would want over the course of eight weeks. The sessions will consist of gamified cognitively demanding exercises that target five cognitive skills: attention, coordination, memory, perception, and reasoning. Participants will also complete the general cognitive function assessment at the end of the intervention period, and the differences between the cognitive scores obtained before and after this period will be used as the main outcome measure. Additional analysis will be performed to better characterize the impact of the CCT by exploring the role of the age of the participants, their self-perceive health at baseline, the intensity of the training and the time from initial COVID-19 infection.

Study Timeline

• Study Start: 2021-12-01
• Primary Completion: 2022-02-28
• Study Completion: 2022-02-28
• Status Verified: 2022-10
• Study First Submitted: 2022-10-03
• Study First Submitted QC: 2022-10-05
• Last Update Submitted: 2022-10-05
• Study First Posted: 2022-10-07
• Last Update Posted: 2022-10-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 73

Inclusion Criteria

• Adults (older than 18 years old).
• History of infection with COVID-19 at least 3 months prior to expression of interest.
• Presence of self-perceived cognitive dysfunction associated with PACS (concentration problems or brain fog).

Exclusion Criteria

• Completion of less than 10 training sessions.
• Not completing the final evaluation after the 8-week training period.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Computerized Cognitive Training	CogniFit's CCT Post COVID-19	Participants will be asked to complete short sessions of around 10 minutes each consisting of a variety of games designed to train the five cognitive skills (attention, memory, coordination, reasoning and perception). Each training session include two games selected among a pool of 12 different games. Participants will be asked to complete a training lasting for 8 weeks in which they could access the training platform as frequently as they wanted.

Primary Outcome Measures

Name	Time	Method
Cognitive Gains	8 weeks	The difference in scores between the initial and final assessments as evaluated by the Cognitive Assessment Battery (CAB)™ PRO

Secondary Outcome Measures

Name	Time	Method
Intensity of the training	8 weeks	Number of minutes dedicated to the CCT

Trial Locations

Locations (1)

Universidad Nebrija; 🇪🇸 Madrid, Spain