ISRCTN42992782Completed未知
High frequency oscillation versus lung-protective ventilation using conventional ventilators to reduce Acute Respiratory Distress Syndrome (ARDS) mortality: a randomised, parallel, two armed, multicentre pilot trial
McMaster University (Canada)0 sites60 target enrollmentStarted: May 31, 2007Last updated:
Trial Snapshot
- Phase
- 未知
- Status
- Completed
- Sponsor
- Enrollment
- 60
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional
Eligibility Criteria
- Sex
- All
Inclusion Criteria
- •1. Patients of either sex, 16 years and above
- •2. Acute onset of respiratory failure, with fewer than two weeks of new pulmonary symptoms
- •3. Endotracheal intubation or tracheostomy
- •4. Hypoxaemia: defined as a partial pressure of oxygen in arterial blood (PaO2)/fraction of inspired oxygen (FiO2) ratio of less than or equal to 200 mmHg
- •5. Bilateral alveolar consolidation (airspace disease) seen on frontal chest radiograph
Exclusion Criteria
- •1. Remaining duration of mechanical ventilation less than 48 hours, as judged by the attending physician
- •2. Primary cause of acute respiratory failure judged by attending physician to be cardiac in origin
- •3. Lack of commitment to ongoing life support
- •4. Weight less than 35 kg
- •5. Severe chronic respiratory disease
- •6. Morbid obesity: defined as greater than 1 kg/cm body height
- •7. Neurological conditions with risk of intracranial hypertension (hypercapnia should be avoided)
- •8. Neuromuscular disease that will result in prolonged need for mechanical ventilation
- •9. Previous enrolment in this trial
- •10. All inclusion criteria present for greater than 72 hours
- •11. On high frequency oscillator (HFO) at the time of screening
Investigators
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