Lactate Levels and Venous Oxygen Saturation in Children Admitted to a Dutch PICU
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- What is the incidence of a decreased ScvO2 and or a raised lactate level in children admitted to Dutch PICU's in the first 24 hours after admission to the PICU
研究概览
简要总结
Observational multicentre cohort study. Children admitted to a Dutch PICU are studied for lactate levels and ScvO2. Children instrumented with arterial and central venous catheters are included within the first 12 hours after admittance.
详细描述
Rationale: Hemodynamic therapy in children with circulatory insufficiency requires the use of hemodynamic monitoring parameters including parameters that reflect tissue/organ oxygenation and oxygen utilization. Two parameters are readily available at the bedside that may reflect this: arterial lactate level and central venous oxygen saturation (ScvO2). To date is it unknown if these parameters are useful in guiding treatment of critically ill children. Also it is unknown how often lactate and ScvO2 are abnormal in children admitted to a Dutch PICU or if they are related to each.
Objective: The objective of this study is to find the incidence of a raised lactate level and or a decreased ScvO2, to study their mutual relation and to study the relation between lactate, ScvO2 and outcome parameters in children admitted to a Dutch PICU.
Study design: Observational cohort study
Study population: children admitted to a PICU <= 16 years
Intervention (if applicable): No intervention
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 1 Week 至 16 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Al children admitted to a PICU <= 16 years equipped with an arterial and central venous catheter in situ at admission or inserted within < 12 hours after admission to the PICU
排除标准
- •Patients without an arterial or central venous catheter > 12 hours after of admission
- •Patients with a known underlying metabolic disorder causing an elevated lactate level
- •Patients with asthma and therapy (nebulized or intravenous) with salbutamol.
- •Patients with an intoxication causing elevated lactate levels
- •Premature children (<38 weeks GA)
- •Patients on ECMO
结局指标
主要结局
What is the incidence of a decreased ScvO2 and or a raised lactate level in children admitted to Dutch PICU's in the first 24 hours after admission to the PICU
时间窗: first 24 hours after admission
What is the incidence of a decreased ScvO2 and or a raised lactate level in children admitted to Dutch PICU's in the first 24 hours after admission to the PICU
次要结局
未报告次要终点
研究者
Joris Lemson
Medical director pediatric intensive care unit
Radboud University Medical Center