Home Air Quality Impact for Adults With Asthma

• Conditions: Asthma; Environmental Exposure; Home Environment Related Disease

• Registration Number: NCT05224076
• Lead Sponsor: University of Kansas Medical Center

Brief Summary

The purposes of this study are to determine the practicality of using home indoor air quality monitoring and a smartphone app to identify home air quality changes and how these changes affect adults with asthma.

Detailed Description

The aims of this feasibility study are: 1) determine the feasibility and usability of: (a) ecological momentary assessment (EMA) to assess self-report residential environmental exposures and asthma symptoms, (b) home monitoring of objective environmental exposures (total volatile organic compounds \[VOCs\], particulates \[PM2.5\]), and lung function (home spirometry); 2a) assess the frequency and degree of residential environmental exposures (e.g., disinfectants/cleaners, second-hand smoke) via (a) self-reported data, and (b) home monitoring objective measures, 2b) assess the level of asthma control as indicated by self-reported asthma symptoms and lung function; and 3) explore associations of self-reported and objective measures of residential environmental exposures with self-reported and objective measures of asthma control. Participants will receive an indoor air quality monitor and a home spirometer to measure VOCs, PM2.5, and forced expiratory volume percent predicted, respectively. EMA will be collected using a personal smartphone and EMA software platform. Participants' will be sent scheduled and random EMA notifications to assess asthma symptoms, environmental exposures, lung function, and mitigation strategies. After the 14-day data collection period, participants will respond to survey items related acceptability, appropriateness, and feasibility.

Study Timeline

• Study First Submitted: 2022-01-10
• Study First Submitted QC: 2022-01-31
• Study First Posted: 2022-02-04
• Study Start: 2022-03-30
• Status Verified: 2022-07
• Last Update Submitted: 2022-07-08
• Last Update Posted: 2022-07-11
• Primary Completion: 2023-03
• Study Completion: 2023-10

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Adults who previously participated in the online Global Covid-19 and Asthma Study, indicated willingness to be contacted for future research, and reported high use of disinfectant/cleaning products since COVID-19 (≥5 per week).
• Current Asthma Control Test (ACT) ≤19
• Own a smartphone
• Have a Wi-Fi/wireless internet connection in their home.

Exclusion Criteria

• Non-US residents
• Non-English speaking

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Home environmental exposure to Volatile organic compounds	Measured continuously for 14 days	Degree of home exposures to volatile organic compounds as measured by the Awair home air quality monitor
Home environmental exposure to particulate matter (PM)	Measured continuously for 14 days	Degree of home exposures to PM2.5 as measured by the Awair home air quality monitor
Asthma control	Assessed daily for 14 days	Forced Expiratory Volume (FEV) Percent predicted as measured by ZEPHYRx home spirometer

Secondary Outcome Measures

Name	Time	Method
Usability of study tools	14 days	Adapted System Usability Scale, 30 items assessing usability of the ZEPHYRx home spirometer, Awair home air quality monitor, and the EMA - with response options of 1= Strongly agree to 5=Strongly Disagree
Compliance with Ecological Momentary Assessment (EMA) prompts	Compliance over 4-hour periods for 14 days	Frequency of responses to daily scheduled, random, and air quality triggered EMA prompts

Trial Locations

Locations (1)

Barbara J Polivka; 🇺🇸 Kansas City, Kansas, United States