Treatment for aqueous deficiency dry eyes
Not Applicable
- Conditions
- Health Condition 1: H041- Other disorders of lacrimal gland
- Registration Number
- CTRI/2020/12/029574
- Lead Sponsor
- V Prasad Eye Institute
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1) Age more than 12 years
2) Patients diagnosed with cicatrizing conjunctivitis or Stevens-Johnson syndrome or Ocular cicatricial pemphigoid having Schirmer I value between 1-5mm
3) If both eyes match the criteria, then eye with less Schirmer value would be chosen
4) Only those who choose the injection modality and give a valid consent (attached) will be enrolled into the study.
Exclusion Criteria
1) Presence of corneal epithelial defects
2) Schirmer value of zero mm
3) Any ocular surgery within past 3 months
4) Any keratoplasty or ocular surface procedure performed during the trial
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.BCVA <br/ ><br>2.Ocular surface disease index <br/ ><br>3.Schirmer I value (without anesthesia) <br/ ><br>4.Corneal and conjunctival hyperemia <br/ ><br>5.Corneal epithelial fluorescein staining <br/ ><br>6.Slit lamp images- unstained, fluorescein, green filter <br/ ><br>7.Tear sampling for future proteomic study <br/ ><br>Timepoint: 1 and 3 months from the last injection
- Secondary Outcome Measures
Name Time Method Corneal and conjunctival hyperemia <br/ ><br>Corneal epithelial fluorescein staining <br/ ><br>Visual acuityTimepoint: Monthly for one year