Drug Patch Tests in Patients With Severe Cutaneous Adverse Reaction to Drugs (SCARs)
Not Applicable
- Conditions
- Drug Reaction
- Interventions
- Other: patch test
- Registration Number
- NCT03176342
- Lead Sponsor
- Chulalongkorn University
- Brief Summary
The study is about drug patch tests in patients who have history of severe cutaneous drug reaction including Steven Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), Drug-induced eosinophilia and systemic symptoms (DRESS), AGEP (Acute generalized exanthematous pustulosis) and generalized bullous fixed drug eruptions. This study also investigate in Enzyme-linked immunosorbent spot assay (ELIspot) and lymphocyte transformation test. We also trying to prove the correlation among result of drug patch tests, ELIspot and LTT.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
- Patients with history of Steven Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), drug-induced eosinophilia and systemic symptoms (DRESS), acute generalized exanthematous pustulosis (AGEP), generalized bullous fixed drug eruption in the past 24 months.
- Age more than 18 years old
Exclusion Criteria
- Receiving immunosuppressive drugs or more than 10 mg/day of prednisolone within 1 month.
- Pregnancy and lactation
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description patch test arm patch test Patch test by selected allergens and drawing blood for ELIspot and LTT
- Primary Outcome Measures
Name Time Method Prevalence of positive drug patch test results. 3 years
- Secondary Outcome Measures
Name Time Method correlation of drug patch test results, ELIspot and lymphocyte transformation test. 3 years
Trial Locations
- Locations (1)
Division of Dermatology, Faculty of Medicine, Chulalongkorn University
🇹ðŸ‡Bangkok, Thailand