To compare the effect of use of both intravenous and intra articular injection of tranexamic acid with only intra-articular injection of tranexamic acid in reducing blood loss in total knee replacement patients in western india

Phase 1

Completed

• Conditions: Osteoarthritis of knee, unspecified,

• Registration Number: CTRI/2018/05/014106
• Lead Sponsor: Yeshi Dorji

Brief Summary

To compare the efficacy of combined group(I.V and intra-articular) vs single group(intra-articular only) in reducing post operative blood loss in primary TKA patients

1gm of TXA is given I.V 15 mins before skin incision and Intra-articular injection is given after closure of joint capsule

Post operatively Heamoglobin and Haematocrit are evaluated on day 3, day5 and day 14

Drain output is measured after 24 hours post operative



Then blood loss of two groups are compared with data collected as mentioned above

Detailed Description

Not available

Study Timeline

• Study Start: 2018-01-06
• Last Update Posted: 2019-06-07
• Study Completion: 2019-06-28

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

In combined Group-1gm of TXA using I.V injection 15 mins before skin incision and 1gm of TXA using intra-articular intra operatively after closure of joint capsule in primary TKA Single group-Receives only 1gm of TXA intra-articular intraoperatively after joint capsule closure in primary TKA.

Exclusion Criteria

Patient unwilling for study-no consent Patients allergic to TXA Patient with known history of thromboembolic disease Patients with cardiovascular disease like MI Patients with history of cerebral vascular disease- stroke pre op renal dysfunction pre op coagulopathy plt less than 1.5lakh and INR more than 1.4.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Compare Fall in Haemoglobin level,haematocrit and Drain output	post operative day Hb level on day 3, day 5 and day 14 | Drain output is measured after 24 hours post surgery

Secondary Outcome Measures

Name	Time	Method
To evaluate the amount of blood loss with combined (intravenous and intra-articular) TXA in primary TKA	To evaluate amount of blood loss with only intra-articular administration of TXA in primary TKA

Trial Locations

Locations (1)

command hospital,pune; 🇮🇳 Pune, MAHARASHTRA, India

command hospital,pune

🇮🇳Pune, MAHARASHTRA, India

Yeshi Dorji

Principal investigator

00917264069572

dorjiyeshi5@gmail.com