Efficacy of Hyaluronic Acid and Platelet-rich Plasma Combination in Knee Osteoarthritis

Phase 4

Completed

• Conditions: Knee Osteoarthritis
• Interventions: Drug: hyaluronic Acid + platelet-rich plasma; Drug: platelet-rich plasma; Drug: hyaluronic acid

• Registration Number: NCT03211650
• Lead Sponsor: University of Milan

Brief Summary

The purpose of this study is to evaluate the efficacy of intra-articular injections of combined hyaluronic acid and platelet-rich plasma in knee degenerative joint disease in improving joint function and reducing pain.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-10-14
• Study First Submitted: 2017-07-06
• Study First Submitted QC: 2017-07-06
• Study First Posted: 2017-07-07
• Primary Completion: 2018-11-30
• Study Completion: 2021-03-27
• Status Verified: 2021-06
• Last Update Submitted: 2021-06-10
• Last Update Posted: 2021-06-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 174

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
hyaluronic acid + platelet-rich plasma	hyaluronic Acid + platelet-rich plasma	Intra-articular injections of hyaluronic acid combined with platelet-rich plasma
platelet-rich plasma	platelet-rich plasma	Intra-articular injections of platelet-rich plasma
hyaluronic acid	hyaluronic acid	Intra-articular injections of hyaluronic acid

Primary Outcome Measures

Name	Time	Method
WOMAC score	6 months after the first intra-articular injection	Comparison of WOMAC total score among three treatment arms

Trial Locations

Locations (2)

U.O.C. 1a Divisione, Azienda Socio Sanitaria Territoriale Centro Specialistico Ortopedico Traumatologico Gaetano Pini-CTO; 🇮🇹 Milano, Milan, Italy

IRCCS Policlinico San Donato; 🇮🇹 San Donato Milanese, Milan, Italy