Bronchospasm Associated With High Nitric Oxide

Completed

• Conditions: Airway Hyperresponsiveness; Asthma

• Registration Number: NCT00666510
• Lead Sponsor: University of Sao Paulo

Brief Summary

Intraoperative bronchospasm challenges anesthesia's safety. This study aims to investigate high concentration of exhaled nitric oxide as a marker of intraoperative bronchospasm.

Detailed Description

Previous studies in asthmatic patients suggested that exhaled nitric oxide may represent a noninvasive measure for airway inflammation. Anesthesia information forms from 1999 throughout 2004 were revised (n=146.358). Bronchospasm occurrence appeared registered on 863 forms. From those, nine were identified as non-asthmatics patients (Bronchospasm group). Also, 12 asthmatics constituted one additional group (Asthma group) and 10 subjects with no previous airway disease or symptoms (Control group). All subjects were submitted to Exhaled nitric oxide measurements (parts/billion), spirometry and induced sputum.

Study Timeline

• Study Start: 1999-01
• Study Completion: 2004-12
• Status Verified: 2008-04
• Study First Submitted: 2008-04-23
• Study First Submitted QC: 2008-04-23
• Last Update Submitted: 2008-04-23
• Study First Posted: 2008-04-25
• Last Update Posted: 2008-04-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 31

Inclusion Criteria

• patients with no systemic disease and registered bronchospasm during anesthesia induction

Exclusion Criteria

• hypertension, COPD, diabetes, pregnancy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Exhaled nitric oxide in parts per billion	one to six months after surgery

Secondary Outcome Measures

Name	Time	Method
Eosinophils concentration within sputum sample, pulmonary function tests	one to six months after surgery

Trial Locations

Locations (1)

Hospital das Clínicas da FMUSP; 🇧🇷 São Paulo, Brazil