Prediction of Postoperative Outcomes After Rectal Resection by the Comprehensive Complication Index (CCI)

Completed

• Conditions: Rectal Diseases

• Registration Number: NCT07037693
• Lead Sponsor: Cantonal Hospital of St. Gallen

Brief Summary

Postoperative complications after rectal resection can worsen the short-term postoperative outcomes and the long-term survival. This study aims to compare the comprehensive complication index (CCI) and the commonly used Clavien-Dindo classification (CDC) in predicting postoperative outcomes after rectal resection.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-01-01
• Primary Completion: 2024-06-30
• Study Completion: 2024-11-30
• Status Verified: 2025-06
• Study First Submitted: 2025-06-06
• Study First Submitted QC: 2025-06-23
• Last Update Submitted: 2025-06-23
• Study First Posted: 2025-06-25
• Last Update Posted: 2025-06-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 958

Inclusion Criteria

• All patients with rectal resection at the Cantonal Hospital of St.Gallen between 2012 and June 2024.

Exclusion Criteria

• Missing CCI data
• Missing CDC data
• Incomplete 30-day follow-up
• Decline to have their information included in the scientific data analysis
• Age under 18 years

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Length of hospital stay	Periprocedural	The predictive ability of the comprehensive-complication index and the Clavien-Dindo classification regarding the length of hospital stay after rectal resection will be compared through an area under the curve (AUC) analysis.

Secondary Outcome Measures

Name	Time	Method
30-day readmission rate	30 days	The predictive ability of the comprehensive-complication index and the Clavien-Dindo classification regarding the 30-day readmission rate after rectal resection will be compared through an area under the curve (AUC) analysis.
90-day mortality	90 days	The predictive ability of the comprehensive-complication index and the Clavien-Dindo classification regarding the 90-day mortality after rectal resection will be compared through an area under the curve (AUC) analysis.
Overall survival	5 years	The patients 5-year overall survival will be compared between patients with low comprehensive-complication index and high comprehensive-complication index. A high comprehensive-complication score was defined as a score above the median score of the patients with a Clavien-Dinco classification grad 3a complication.
Comprehensive measure	30 days	Evaluation of the comprehensive measure of the comprehensive-complications index through analysis of the number and severity of all complications for patients with multiple complications. Comparison of the range of the comprehensice complications-index score in patients with the same Clavien-Dindo classification.

Trial Locations

Locations (1)

HOCH Health Ostschweiz, Kantonsspital St.Gallen; 🇨🇭 St.Gallen, Switzerland