Tour de Borobudur Troponin Study on Predictors and Synergistic Role of MDA and Hs-CRP Levels

Completed

Conditions: Heart Arrest
Inflammatory Response
Oxidative Stress
Sport Injury

Brief Summary: Prospective observational study to determine predictors that related to cardiac troponin I (cTnI) release, malondialdehyde (MDA) and high sensitivity C Reactive Protein (hs-CRP) after Tour de Borobudur (TdB) 2017

Detailed Description: Eligible Criteria:

1. minimum sample size of 80 men, non-athlete, participants of TdB

2. Classified into two groups: 160kms cycling and 100kms cycling participation

3. 25-55 years old

4. voluntary participate in the research

5. eligible in pre participatory physical examination and ECG test by the doctor

6. have no history of the previous acute coronary syndrome (ACS)

Measurements:

Interview for determining predictors of sports participation history, medical history, family medical history and Rate of Perceived Exertion Measurement and examination to determine: anthropometry parameters, clinical conditions (Systolic BP, Diastolic BP, hemoglobin levels, T-cholesterol and HDL-C levels, the intensity in cycling activities (mileage, velocity, duration, and time for resting), hemodynamic responses (average and maximum heart rate, Karvonen Index), and Hydration status

Other outcome measurements; pre and post-TdB 2017 measurements of cTnI, MDA, and hs-CRP

Recruitment & Eligibility

Inclusion Criteria

minimum sample size of 80 men, non athlete, participants of TdB
Classified into two groups: 160kms cycling and 100kms cycling participation
25-55 years old
voluntary participate in the research
eligible in pre participatory physical examination and ECG test by doctor have no history of previous acute coronary syndrome (ACS)

Exclusion Criteria

stop cycling before finish line due to mechanical or bicycle related errors
(subjects who stop cycling due to any physical symptoms and health related problem included in analysis)

Arm && Interventions

Group	Intervention	Description
Group 140kms cycling	140kms cycling	Participants of Tour de Borobudur 2017 140 km cycling touring and willing to participate in the study. Investigator did not give any intervention, just observed the cycling touring event that the subjects participated
Group 100kms cycling	140kms cycling	Participants of Tour de Borobudur 2017 100 km cycling touring and willing to participate in the study. Investigator did not give any intervention, just observed the cycling touring event that the subjects participated
Group 240kms cycling	140kms cycling	Participants of North Coast 2017 240 km cycling touring and willing to participate in the study. Investigator did not give any intervention, just observed the cycling touring event that the subjects participated

Primary Outcome Measures

Name	Time	Method
Cardiac Troponin I (cTnI)	immediate after TdB 2017 cycling touring within less than 5 min	specific protein to determine cardiac injury
Malondialdehyde (MDA)	immediate after TdB 2017 cycling touring within less than 5 min	oxydative stress marker

Secondary Outcome Measures

Name	Time	Method
Number of Participants With Pathological ECG Appearance	immediate after TdB 2017 cycling touring within less than 5 min	Number of Participants with Pathological ECG Appearance. Pathological ECG appearance was the results of the ECG test describing one of the pathological appearances in ECG i.e.: 1. The pathological rhythm which is may consist of Atrial Flutter, Atrial Fibrillation, Supraventricular Tachycardia, Ventricular Fibrillation, First Degree Heart Block, Second Degree Heart Block, Type 1 - Mobitz I, Second Degree Heart Block, Type 2 - Mobitz II, Third Degree Heart Block, or other pathological rhythm appearances 2. Pathological ST-segment i.e. ST elevation (early repolarization), or another form 3. Pathological U wave, and 4. other pathological appearances
High Sensitivity C Reactive Protein (Hs-CRP)	immediate after TdB 2017 cycling touring within less than 5 min	a biomarker that represents the inflammation process