A study of Renal Denervation for Heart Failure with Preserved Ejection Fraction to reduce left atrial volume index (LAVi) and/or left ventricular mass index (LVMi) on cardiac magnetic resonance imaging (cMRI).

Christchurch Heart Institute0 个研究点目标入组 20 人开始时间: 2013年5月15日最近更新: 2020年1月13日

适应症

试验速览

暂无简介。

•*Patients with HFPEF (based upon ESC diagnostic criteria)
•a. Symptoms and signs of heart failure; NYHA Class II or higher
•b. Left ventricular ejection fraction 50% or greater on echocardiography
•c. Echocardiographic evidence of left ventricular diastolic dysfunction (echo-Doppler E/e’ > 15 ) AND/OR plasma NTproBNP > 220pg/ml.
•*Episode of acute decompensation (ADHF) requiring hospital admission within the 12 months prior to recruitment
•*Patients with and without background hypertension may be recruited. In the case of patients with background hypertension (ie history of fulfilling the diagnostic WHO criteria for hypertension: SBP > 140 mmHg and/or DBP > 90 mmHg) those with both controlled (<140/90mmHg by 24 hour ambulatory BP) and inadequately controlled BP (on 3 anti-hypertensive drugs including a diuretic) can be recruited.

•*Known secondary cause of hypertension
•*Renal artery stenosis >30% or anatomy otherwise unsuitable for RDN.
•* Heart failure with reduced LV ejection fraction (LVEF < 50%).
•*Estimated glomerular filtration rate (eGFR) of < 30mL/min/1.73m2 (MDRD calculation).
•*Systolic blood pressure < 105mmHg.
•*Implanted pacemaker, prosthetic heart valve or other precluding cMR scanning.
•*Medical condition adversely affecting safety and/or effectiveness of the participant (including peripheral vascular disease, abdominal aortic aneurysm, thrombocytopenia or uncontrolled atrial fibrillation).
•*Pregnant, nursing or planning to be pregnant.

发起方

Christchurch Heart Institute