The effect of dietary nitrate supplementation on blood pressure and exercise capacity in people with COPD

Not Applicable

Completed

• Conditions: Respiratory; Stable COPD

• Registration Number: ISRCTN47839214
• Lead Sponsor: Imperial College, London

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-11-01
• Study Completion: 2022-03-01
• Last Update Posted: 21 March 2022

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 81

Inclusion Criteria

1. Adult patients (>21 years) with stable COPD GOLD I-IV
2. Established on stable pharmacotherapy for COPD
3. Systolic blood pressure >130 mmHg

Exclusion Criteria

1. Unable to provide informed consent
2. AECOPD in the preceding month
3. Significant comorbidity limiting exercise tolerance
4. Significant comorbidity limiting life expectancy
5. Significant renal impairment (estimated glomerular filtration rate (eGFR) <30 ml.min1)
6. Use of >3 blood pressure lowering medications
7. Change in medication in the previous month
8. Oral nitrate medication
9. Current (in the last month) use of Beet Shots

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Home-monitored blood pressure measured using ambulatory blood pressure monitoring at baseline and 3 months