Prospective Cohort Study of Association of Insulin Resistance/Steatosis With Hepatic Fibrosis in CHB and NAFLD

Completed

• Conditions: Hepatic Fibrosis; Fatty Liver; Chronic Hepatitis B

• Registration Number: NCT02031913
• Lead Sponsor: Seoul National University Boramae Hospital

Brief Summary

Hepatic steatosis and insulin resistance are associated with severity of fibrosis in non-alcoholic fatty liver disease (NAFLD) and chronic hepatitis C. However, clinical significance of steatosis and insulin resistance on fibrosis in chronic hepatitis B (CHB) is not well established. The aim was to investigate the relationship between insulin resistance, hepatic steatosis, and fibrosis in patients with CHB.

Detailed Description

acoustic radiation force impulse elastography

Study Timeline

• Study Start: 2013-01
• Study First Submitted: 2014-01-08
• Study First Submitted QC: 2014-01-08
• Study First Posted: 2014-01-09
• Primary Completion: 2022-11
• Study Completion: 2022-12
• Status Verified: 2023-04
• Last Update Submitted: 2023-04-11
• Last Update Posted: 2023-04-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 500

Inclusion Criteria

• Chronic hepatitis B patients
• With evidences of hepatic steatosis on ultrasonography or pathology

Exclusion Criteria

• significant alcohol consumption or other known liver diseases

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Insulin resistance and fibrosis indices	one year	Measurement for insulin resistance and fibrosis index for hepatic fibrosis assessment

Trial Locations

Locations (1)

Seoul Metropolitan Government Seoul National University; 🇰🇷 Seoul, Korea, Republic of