High versus Low volume plasma exchange in liver failure
Not Applicable
- Conditions
- Health Condition 1: K729- Hepatic failure, unspecified
- Registration Number
- CTRI/2019/06/019660
- Lead Sponsor
- Post Graduate Institute of Medical Education and Research Chandigarh
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1. First episode of de-compensation with AARC-ACLF (APASL (Asian Pacific Association for the Study of the Liver) ACLF (Acute on Chronic Liver Failure) Research Consortium (AARC) grade I or II (AARC score <10)
2.No evidence of active infection
3.Willing to give informed consent for the procedure
Exclusion Criteria
1.Pregnancy
2.Co-existing HCC or extra-hepatic malignancy
3.Microbiological or radiological evidence of active infection
4.Active hemorrhage
5.Multi-organ failure(>= 3 organ failures)
6.APASL-AARC score >10
7.Known allergy to Plasma, Protamine or Heparin.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the efficacy (in term of change of clinical grade of severity) and tolerability (in terms of adverse events related to procedure) of standard (one) volume plasma exchange Vs high volume plasma exchange in acute on chronic liver failure patientsTimepoint: Day 0, Day 4, day 30 and day 90
- Secondary Outcome Measures
Name Time Method To estimate the effect of different volume exchange procedure on biochemical parameters and Cytokine levels (IL6 IL10 and TNFα) <br/ ><br>To compare the effect of different volume exchange procedures on 30 & 90 day mortality. <br/ ><br>Timepoint: Day 0 to day 4 for biochemical and laboratory parameters and day 30 and day 90 for mortality