NCT02127333已完成不适用
Role of Acute and Chronic Hypoxemia for Vascular Function
Klinik für Kardiologie, Pneumologie und Angiologie1 个研究点 分布在 1 个国家目标入组 38 人开始时间: 2011年1月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 38
- 试验地点
- 1
- 主要终点
- Flow-mediated dilation of the brachial artery
研究概览
简要总结
Hypoxemia may contribute increased morbidity and mortality in chronic obstructive pulmonary disease (COPD) patients. We aim to characterize the role of acute and chronic hypoxemia for vascular function. For this purpose we measure capillary oxygen concentration and vascular.
Vascular function is assessed by flow-mediated dilation oft he brachial artery, forearm blood flow and laser doppler perfusion imaging.
We hypothesize that hypoxemia leads to impaired vascular function.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 40 Years 至 80 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •stable coronary artery disease
- •stable chronic obstructive pulmonary disease
排除标准
- •acute myocardial infarction within 30 days
- •acute exacerbated COPD within 30 days
- •acute infections
- •severe acute or chronic renal failure
- •severe heart failure
- •atrial fibrillation
- •severe cardiac arrhythmia
- •hypotension
- •active malignant disease
- •active rheumatic disease
- •pulmonary hypertension with vasoactive therapy
结局指标
主要结局
Flow-mediated dilation of the brachial artery
时间窗: Baseline
次要结局
- Fractional diameter change of the brachial artery(Baseline)
- Intima-media thickness of the brachial artery(Baseline)
- Forearm blood flow(Baseline)
- Laser doppler perfusion(Baseline)
- Endothelium-independent vasodilation of the brachial artery(Baseline)
研究者
Klinik für Kardiologie, Pneumologie und Angiologie
Division of Cardiology, Pulmonary Diseases, Vascular Medicine
Heinrich-Heine University, Duesseldorf
研究点 (1)
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