NCT02127333
Completed
Not Applicable
Role of Acute and Chronic Hypoxemia for Vascular Function
Klinik für Kardiologie, Pneumologie und Angiologie1 site in 1 country38 target enrollmentJanuary 2011
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Endothelial Dysfunction
- Sponsor
- Klinik für Kardiologie, Pneumologie und Angiologie
- Enrollment
- 38
- Locations
- 1
- Primary Endpoint
- Flow-mediated dilation of the brachial artery
- Status
- Completed
- Last Updated
- 11 years ago
Overview
Brief Summary
Hypoxemia may contribute increased morbidity and mortality in chronic obstructive pulmonary disease (COPD) patients. We aim to characterize the role of acute and chronic hypoxemia for vascular function. For this purpose we measure capillary oxygen concentration and vascular.
Vascular function is assessed by flow-mediated dilation oft he brachial artery, forearm blood flow and laser doppler perfusion imaging.
We hypothesize that hypoxemia leads to impaired vascular function.
Investigators
Klinik für Kardiologie, Pneumologie und Angiologie
Division of Cardiology, Pulmonary Diseases, Vascular Medicine
Heinrich-Heine University, Duesseldorf
Eligibility Criteria
Inclusion Criteria
- •stable coronary artery disease
- •stable chronic obstructive pulmonary disease
Exclusion Criteria
- •acute myocardial infarction within 30 days
- •acute exacerbated COPD within 30 days
- •acute infections
- •severe acute or chronic renal failure
- •severe heart failure
- •atrial fibrillation
- •severe cardiac arrhythmia
- •hypotension
- •active malignant disease
- •active rheumatic disease
Outcomes
Primary Outcomes
Flow-mediated dilation of the brachial artery
Time Frame: Baseline
Secondary Outcomes
- Fractional diameter change of the brachial artery(Baseline)
- Intima-media thickness of the brachial artery(Baseline)
- Forearm blood flow(Baseline)
- Laser doppler perfusion(Baseline)
- Endothelium-independent vasodilation of the brachial artery(Baseline)
Study Sites (1)
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