Influence of Chronic Hypoxia on Oxidative Phenotype in Patients With Chronic Obstructive Pulmonary Disease
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 13
- 试验地点
- 1
- 主要终点
- Level of expression of muscle messenger ribonucleic acid (mRNA) of HIF-1α and PGC-1α
研究概览
简要总结
In addition to chronic airflow obstruction, patients with Chronic Obstructive Pulmonary Disease (COPD) suffer from skeletal muscle dysfunction which is a prominent and disabling feature and also an independent determinant of survival. Muscular impairment involves loss of muscle oxidative phenotype (OXPHEN: a slow-to-fast shift in fibre types and reduced oxidative capacity). Since hypoxia obviously is a key feature of COPD, the aim of this study is to elucidate the role of hypoxia in loss of muscle OXPHEN.
Thus, OXPHEN and expression levels of its key regulators will be determined in the baseline biopsies for association with the degree of hypoxemia. In addition, expression levels of the key OXPHEN regulators will be measured in pre/post exercise biopsies.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of COPD confirmed according to GOLD score.
- •Hypoxemia group: resting arterial paO2 <55 mmHg.
- •Normoxemia group : resting arterial paO2 > 67 mmHg
排除标准
- •Unstable cardiorespiratory status (acute respiratory failure)
- •Oxygen treatment started
- •Inclusion in a pulmonary rehabilitation program in the last 6 months
- •Anticoagulant treatment
结局指标
主要结局
Level of expression of muscle messenger ribonucleic acid (mRNA) of HIF-1α and PGC-1α
时间窗: Day 1
Comparison of expression levels of Hypoxia-inducible Factors (HIF-1α) and Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PGC-1α), two OXYPHEN regulators, in muscle biopsy, between COPD patients with chronic hypoxemia and those with normoxemia
次要结局
- Oxidative enzyme capacity(Day 1)
- Level of expression of muscle mRNA of PGC-1α after acute exercise(Day 1)
- Type I muscle fibers(Day 1)
- Level of expression of muscle mRNA of HIF-1α after acute exercise(Day 1)