Role of Oxygen for Vascular Dysfunction

Completed

• Conditions: FMD; Oxygen Pressure; Carbon Dioxide Pressure; Microcirculation; Endothelial Dysfunction; IMT; Oxygen Saturation; Forced Expiratory Volume After 1 Second

• Registration Number: NCT02127333
• Lead Sponsor: Klinik für Kardiologie, Pneumologie und Angiologie

Brief Summary

Hypoxemia may contribute increased morbidity and mortality in chronic obstructive pulmonary disease (COPD) patients. We aim to characterize the role of acute and chronic hypoxemia for vascular function. For this purpose we measure capillary oxygen concentration and vascular.

Vascular function is assessed by flow-mediated dilation oft he brachial artery, forearm blood flow and laser doppler perfusion imaging.

We hypothesize that hypoxemia leads to impaired vascular function.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-01
• Primary Completion: 2013-09
• Study Completion: 2013-09
• Study First Submitted: 2014-04-29
• Study First Submitted QC: 2014-04-29
• Study First Posted: 2014-04-30
• Status Verified: 2014-12
• Last Update Submitted: 2014-12-14
• Last Update Posted: 2014-12-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 38

Inclusion Criteria

• stable coronary artery disease
• stable chronic obstructive pulmonary disease

Exclusion Criteria

• acute myocardial infarction within 30 days
• acute exacerbated COPD within 30 days
• acute infections
• severe acute or chronic renal failure
• severe heart failure
• atrial fibrillation
• severe cardiac arrhythmia
• hypotension
• active malignant disease
• active rheumatic disease
• pulmonary hypertension with vasoactive therapy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Flow-mediated dilation of the brachial artery	Baseline

Secondary Outcome Measures

Name	Time	Method
Forearm blood flow	Baseline
Laser doppler perfusion	Baseline
Intima-media thickness of the brachial artery	Baseline
Fractional diameter change of the brachial artery	Baseline
Endothelium-independent vasodilation of the brachial artery	Baseline

Trial Locations

Locations (1)

Division of Cardiology, Pulmonary Disease and Vascular Medicine; 🇩🇪 Düsseldorf, Germany