NCT02794012已完成不适用
Periodontal Inflammation and Immunity in Preclinical Rheumatoid Arthritis
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 146
- 试验地点
- 1
- 主要终点
- Degree of periodontal disease by oral examinations according to the American Academy of Periodontology (AAP) guidelines
研究概览
简要总结
The purpose of this study is to evaluate the association of Rheumatoid Arthritis (RA)-related antibodies and periodontal inflammation in subjects at-risk for Rheumatoid Arthritis. Subjects will undergo periodontal and joint examinations, as well as collection of body fluids to measure Rheumatoid Arthritis-related antibodies.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 99 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Rheumatoid Arthritis-antibody positivity (anti-CCP) in the absence of arthritis or
- •Early RA <36 months since diagnosis
排除标准
- •Pregnancy
- •Antibiotic use prior to dental procedures or cleanings
- •Wear dentures
- •<18 years old
结局指标
主要结局
Degree of periodontal disease by oral examinations according to the American Academy of Periodontology (AAP) guidelines
时间窗: 1 day
次要结局
- Frequency of bacterial communities of the periodontium by bacterial diversity (e.g. Shannon Diversity Index) and bacterial load (qPCR)(1 day)
- Frequency of Rheumatoid Arthritis-related antibodies in blood and mucosal sites using Rheumatoid Factor and Anti-Citrullinated Protein Antibody assays(1 day)
研究者
研究点 (1)
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