Evaluation of Physiological Effects of Noninvasive Mechanical Ventilation and High-flow Oxygen Therapy for Acute Exacerbations of Interstitial Lung Diseases

ADIR Association1 site in 1 country18 target enrollmentJanuary 1, 2024

ConditionsInterstitial Lung Disease Acute Respiratory Failure

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Interstitial Lung Disease
Sponsor: ADIR Association
Enrollment: 18
Locations: 1
Primary Endpoint: Pulmonary compliance
Status: Not yet recruiting
Last Updated: 2 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The objectives of this study are to compare the physiological consequences of high-flow oxygen therapy and noninvasive mechanical ventilation on ventilation, respiratory work and hemodynamics during acute respiratory failure in diffuse interstitial pneumonia.

Registry

clinicaltrials.gov

Start Date

January 1, 2024

End Date

December 31, 2026

Last Updated

2 years ago

Study Type

Interventional

Study Design

Crossover

Sex

All

Investigators

Sponsor

ADIR Association

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Outcomes

Primary Outcomes

Pulmonary compliance

Time Frame: During the intervention, after an exposure of 30 minutes to the oxygen therapy device

Comparison of global pulmonary compliance (Cglob) under noninvasive ventilation (NIV) and high-flow oxygen therapy (HFO) during acute respiratory failure in diffuse interstitial pneumonia.

Secondary Outcomes

transpulmonary pressure(During the intervention, after an exposure of 30 minutes to the oxygen therapy device)
end-expiratory lung volume(During the intervention, after an exposure of 30 minutes to the oxygen therapy device)
respiratory rate(During the intervention, after an exposure of 30 minutes to the oxygen therapy device)
inspiratory time(During the intervention, after an exposure of 30 minutes to the oxygen therapy device)
ultrasound diaphragmatic strain.(During the intervention, after an exposure of 30 minutes to the oxygen therapy device)
diaphragmatic thickening fraction(During the intervention, after an exposure of 30 minutes to the oxygen therapy device)
Pulmonary compliance(During the intervention, after an exposure of 30 minutes to the oxygen therapy device)
oesophagal pressure swings(During the intervention, after an exposure of 30 minutes to the oxygen therapy device)
Tidal volume(During the intervention, after an exposure of 30 minutes to the oxygen therapy device)
oesophagal pressure time products(During the intervention, after an exposure of 30 minutes to the oxygen therapy device)
cardiac output(During the intervention, after an exposure of 30 minutes to the oxygen therapy device)
heart rate(During the intervention, after an exposure of 30 minutes to the oxygen therapy device)
driving pressure(During the intervention, after an exposure of 30 minutes to the oxygen therapy device)
Global inhomogeneity index(During the intervention, after an exposure of 30 minutes to the oxygen therapy device)
Systolic arterial pressures(During the intervention, after an exposure of 30 minutes to the oxygen therapy device)
systolic pulmonary arterial pressure(During the intervention, after an exposure of 30 minutes to the oxygen therapy device)
tricuspid annular plane systolic excursion(During the intervention, after an exposure of 30 minutes to the oxygen therapy device)
transdiaphragmatic pressure variations(During the intervention, after an exposure of 30 minutes to the oxygen therapy device)
peak inspiratory flow(During the intervention, after an exposure of 30 minutes to the oxygen therapy device)
Diastolic arterial pressures(During the intervention, after an exposure of 30 minutes to the oxygen therapy device)
Mean arterial pressure(During the intervention, after an exposure of 30 minutes to the oxygen therapy device)
Pulsed oxymetry(During the intervention, after an exposure of 30 minutes to the oxygen therapy device)
Dyspnea(During the intervention, after an exposure of 30 minutes to the oxygen therapy device)
Comparison of Comfort(During the intervention, after an exposure of 30 minutes to the oxygen therapy device)
transdiaphragmatic pressure time products(During the intervention, after an exposure of 30 minutes to the oxygen therapy device)
peak expiratory flow(During the intervention, after an exposure of 30 minutes to the oxygen therapy device)
left ventricular ejection fraction(During the intervention, after an exposure of 30 minutes to the oxygen therapy device)
E/E' ratio(During the intervention, after an exposure of 30 minutes to the oxygen therapy device)
right auricular pressure(During the intervention, after an exposure of 30 minutes to the oxygen therapy device)
transcutaneous carbon dioxide pressure(During the intervention, after an exposure of 30 minutes to the oxygen therapy device)
right ventricular strain(During the intervention, after an exposure of 30 minutes to the oxygen therapy device)