NCT04212182
Unknown
Not Applicable
The Physiological Effect of High Flow Oxygen Therapy on Acute Exacerbation of Chronic Obstructive Pulmonary Disease
The First Affiliated Hospital of Guangzhou Medical University1 site in 1 country10 target enrollmentDecember 27, 2019
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- High-flow Nasal Cannula
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
- Enrollment
- 10
- Locations
- 1
- Primary Endpoint
- Neural respiratory drive
- Last Updated
- 6 years ago
Overview
Brief Summary
Although non-invasive positive pressure ventilation (NPPV) shows the good curative effect of treating the patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD), some patients do not tolerate NPPV or do not benefit from it. High-flow nasal cannula (HFNC) is well tolerated and may be used to patients with AECOPD who are intolerant to NPPV treatment. This study is to evaluate the physiological effect of HFNC and compare it with NPPV.
Investigators
Rongchang Chen
Principal Investigator
The First Affiliated Hospital of Guangzhou Medical University
Eligibility Criteria
Inclusion Criteria
- •AECOPD patients with acute hypercapnic respiratory failure
Exclusion Criteria
- •other lung/pleural diseases or thoracic deformity
- •severe heart failure (New York Heart Association class IV), severe dysrhythmia
- •unstable angina, or malignant comorbidity
- •obesity (BMI ≥ 35 kg/m²)
- •severe obstructive sleep apnea syndrome
Outcomes
Primary Outcomes
Neural respiratory drive
Time Frame: 30 minutes
Neural respiratory drive is calculated by diaphragm electromyogram
Secondary Outcomes
- Work of breathing(30 minutes)
- Transcutaneous CO2(30 minutes)
Study Sites (1)
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