The Effects of Vertical Position on Gas Exchange in Patients With Respiratory Failure
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 16
- 试验地点
- 1
- 主要终点
- PaO2 to FiO2 ratio
研究概览
简要总结
The purpose of this study is to investigate how changing from a supine to upright position affects gas exchange for patients with hypoxemic respiratory failure.
The research question is: will oxygen saturation and/or partial pressure of oxygen in the blood change when a patient with hypoxemic respiratory failure moves from a supine to upright position?
详细描述
Our hypothesis is that blood oxygen tension will not decrease and may even increase when a patient with respiratory failure stands up. Supine positioning often causes partial lung collapse, which results in a decreased amount of lung being available for gas exchange. In patients with Acute Respiratory Distress Syndrome (ARDS), tilting the patient up in bed has been shown to increase oxygen tension and improve lung compliance. Positional changes are sometimes used as a "rescue" intervention in patients with severe hypoxemia from ARDS. The investigators hope to conclude that severe hypoxemia should not be viewed as a contraindication to physical therapy, but rather physical therapy may be a potential intervention for patients with marginal gas exchange.
After sedative interruption, physical therapists and nursing staff will assist mechanically ventilated patients in moving to the side of the bed. They will assess the extremity strength using the MRC scale. If lower extremity strength is at least 4/5, the patient will be assisted to assume the upright position. The investigators will monitor the patient continuously and the session will be stopped at any point for
A. Mean arterial pressure <65 B. Heart rate <40, >130 beats/min C. Respiratory rate <5, >40 breaths/ min D. Pulse oximetry <88% E. Marked ventilator dyssynchrony F. Patient distress G. New arrhythmia H. Concern for myocardial ischemia I. Concern for airway device integrity J. Endotracheal tube removal
At this point, the patient's vital signs, pulse oximetry, and measures of lung compliance will be obtained. If an arterial line is in place and there have been ventilator adjustments since the morning arterial blood gas, the investigators will draw an arterial blood gas.
The physical therapists and nursing staff will then help the patient stand up. After one minute, the investigators will record another set of vital signs, pulse oximetry, and measures of lung compliance from the mechanical ventilator. If an arterial line is in place, the investigators will draw another arterial blood gas.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients aged ≥18 years who are mechanically ventilated
- •An oxygen saturation of 88-94% or an arterial line
排除标准
- •Mean arterial pressure <65
- •Heart rate < 40 or > 130 beats/min
- •Respiratory rate < 5 or > 40 breaths/min
- •Pulse oximetry < 88%
- •Evidence of elevated intracranial pressure
- •Active gastrointestinal blood loss
- •Active myocardial ischemia
- •Pregnancy
- •Actively undergoing a procedure
- •Patient agitation requiring increased sedative administration in the last 30 mins
- •Insecure airway (device)
- •The patient was not ambulatory prior to hospitalization
- •The patient's body habitus and/or mental status make it unsafe to stand up
- •The patient has been placed on strict bed rest by the treating physicians
研究组 & 干预措施
Mechanically Ventilated
干预措施: Standing (Other)
结局指标
主要结局
PaO2 to FiO2 ratio
时间窗: change from baseline to 1 hr
次要结局
- Oxygen Saturation(change from baseline to 1 hr)
- change in blood PCO2(change from baseline to 1 hr)
- Change in blood pH(change from baseline to 1hr)