Influence of Head Elevation in Prone Position on Gas Exchange and Lung Mechanics in Patients With ALI/ARDS
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- PaO2/FiO2 ratio
研究概览
简要总结
Semi-recumbent position leads to improvement of gas exchange and lung mechanics in patients suffering from ALI or ARDS. Prone positioning leads to similar effects. To date, no data on the combination of these two positioning measures exist. The investigators hypothesize that head elevation in prone position leads to improvement in gas exchange and lung mechanics.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 89 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Mechanically ventilated
- •ALI or ARDS
- •No contraindications for prone position
排除标准
- •Patient < 18 or > 89 years old
- •Pregnancy
- •Elevated intracranial pressure
- •PaO2/FiO2 - ratio < 60
- •Open abdomen
- •Instable spine
- •Malignant arrhythmias
- •Severe hemodynamic instability
研究组 & 干预措施
1
Start with turning to prone position without head elevation, after 2 hours 30° head elevation, after 2 hours back to PP without head elevation.
干预措施: Prone position with head elevation (Procedure)
2
Start with turning to prone position with 30° head elevation, after 2 hours PP without head elevation, after 2 hours back to 0° PP.
干预措施: Prone position with head elevation (Procedure)
结局指标
主要结局
PaO2/FiO2 ratio
时间窗: Study period (5 hours on 2 consecutive days)
次要结局
- PaCO2, Compliance (Chest wall, lung, respiratory system)(Study period (5 hours on 2 consecutive days))