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临床试验/NCT05246605
NCT05246605招募中不适用

Postoperative Hypoxia and Body Position

Umeå University2 个研究点 分布在 1 个国家目标入组 34 人开始时间: 2022年3月16日最近更新:
适应症

试验速览

阶段
不适用
状态
招募中
入组人数
34
试验地点
2
主要终点
Mean change in oxygen partial pressure in supine vs. prone position.

研究概览

简要总结

The study aims at investigate whether the oxygen partial pressure is improved in the prone position postoperative after abdominal surgery. Included are 50 adults operated with abdominal surgery. The Intervention is turning from supine to prone position and then back to supine position while measuring whether an improvement occurs in oxygen saturation and oxygen partial pressure, or not.

详细描述

Postoperative hypoxia complicates 30% - 50% of abdominal surgeries. The cause of postoperative restrictive lung function and hypoxia is unknown. Previous studies report that oxygen partial pressure decreases by an average of 2 kPa after abdominal surgery, while carbon dioxide partial pressure is unchanged and vital capacity decreases by 35%. Patients are operated and treated in the post anesthesia care unit in the supine position. The study aims at investigate whether the oxygen partial pressure is improved in the prone position postoperative after abdominal surgery or not.

Inclusion: 50 adults operated with abdominal surgery. Exclusion: Esophageal surgery, Abdominal vessel surgery. Decline participation. Intervention: turning from supine to prone position and then back to supine position again.

Primary outcome: Change in oxygen saturation and oxygen partial pressure. Secondary outcome: Change in carbondioxide partial pressure Procedures: Partial blood gas is taken before surgery. On the day of surgery or the day after: starting in supine position with continuous measurements of oxygen saturation from pulse oximetry, transcutaneous carbon-dioxide partial pressure and blood gas. Then turning to prone position and then back to supine position.

研究设计

研究类型
Interventional
分配方式
Na
干预模型
Sequential
主要目的
Treatment
盲法
None

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Being operated within 2 in the abdomen because of upper gastrointestinal surgery, colorectal surgery, urological surgery or emergency surgery
  • Must be able to turn from supine position to prone position in the bed

排除标准

  • Esophageal surgery, Abdominal vessel surgery.
  • Decline participation.

结局指标

主要结局

Mean change in oxygen partial pressure in supine vs. prone position.

时间窗: Through study completion, an average of 1 year

Oxygen partial pressure

Mean change in oxygen saturation pressure in supine vs. prone position.

时间窗: Through study completion, an average of 1 year

Oxygen saturation

次要结局

  • Mean change in carbon dioxide partial pressure pressure in supine vs. prone position.(Through study completion, an average of 1 year)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Karl A Franklin

Profesor, Consultant surgeon

Umeå University

研究点 (2)

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