Short-term Effects of Prone Positioning on Tissue Oxygen Saturation, Measured by Near-infrared Spectroscopy, in COVID-19 Patients With Acute Respiratory Distress Syndrome
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Covid19
- Sponsor
- Corporacion Parc Tauli
- Enrollment
- 100
- Locations
- 6
- Primary Endpoint
- Change in local hemoglobin content (THC)
- Last Updated
- 3 years ago
Overview
Brief Summary
The purpose of this study is to monitor short-term changes in tissue oxygen saturation and local blood flow as results of changing from supine to prone position in ARDS COVID-19 patients
Detailed Description
After obtaining consent to participate in the study, the subjects included in the study will undergo a baseline 15-minute measurement of tissue oxygen saturation (StO2) measured non-invasively on the forearm by means of near-infrared spectroscopy (NIRS). Once a baseline stable StO2 value is obtained, a provocative test, consisting of a transient vascular occlusion, will be performed. The test will allow the obtention of a local metabolic rate, and a StO2 recovery rate after the ischemic stimulus. Tissue oxygenation measurements will be performed in supine position, immediately before changing to prone positioning, and repeated after 20 minutes of stabilization, once in prone position.
Investigators
Jaume Mesquida
Principal Investigator
Corporacion Parc Tauli
Eligibility Criteria
Inclusion Criteria
- •COVID-19 patients admitted in the ICU receiving invasive mechanical ventilation and requiring prone positioning for severe hypoxemia management, as decided by the medical team
Exclusion Criteria
- •Severe peripheral vasculopathy
- •Raynaud's syndrome
- •Skin lesions/trauma in upper limbs interfering the placement of the NIRS probe and/or the occlusion tourniquet
- •Deep venous thrombosis in the upper limbs
Outcomes
Primary Outcomes
Change in local hemoglobin content (THC)
Time Frame: 20 minutes
THC is measured as microMols
Change in tissue oxygenation (StO2)
Time Frame: 20 minutes
Tissue oxygenation is measured as percent of oxyhemoglobin over total hemoglobin content in the sensed area (skeletal muscle)
Secondary Outcomes
- Compare changes in tissue oxygenation (StO2) and arterial oxygenation (SaO2)(20 minutes)