Evaluation of Platelet-Rich Fibrin with and without Aspirin complex in the management of bilateral mandibular grade-II furcation defects- A Randomized Clinical Trial
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- Self
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Comparative assessment of grade 2 furcation defect fill with PRF and PRF aspirin complex
研究概览
简要总结
A randomized clinical trial will be conducted by the Department of Periodontology, Narayana Dental College and Hospital, Nellore, Andhra Pradesh, India.
A total of 30 patients with mandibular grade-II furcation defects will be selected . After full mouth scaling and root planing selected patients will be assigned to following groups.
Group A: Open Flap Debridement (OFD) with PRF.
Group B: Open Flap Debridement (OFD) with PRF-ASPIRIN COMPLEX.
Gingival index (GI), Plaque Index (PI),Probing Depth (PD),Clinical Attachment Level and Standardized radiographic recordings will be done at baseline and 6 months.
All the parameters will be subjected for statistical analysis after completion of the study to evaluate and compare the bone fill between the groups in grade-II furcation defects .
Significant difference was found in both clinical and radiographic measurements in both groups.Significant radiographic bone fill was observed in PRF-A group
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Investigator Blinded
入排标准
- 年龄范围
- 35.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •1.Bilateral mandibular grade II furcation defects according to Glickman’s classification.
- •2.Systemic diseases known to influence the periodontal condition and not receiving any medication known to affect the status.
排除标准
- •2.Pregnant females.
- •3.Patient who are under antibiotic coverage for past 1 month.
- •4.Patients who had received periodontal therapy with in 6months before study are excluded.
- •5.Patients who are known hypersensitivity or allergy to aspirin are excluded.
- •6.History of alcohol abuse.
结局指标
主要结局
Comparative assessment of grade 2 furcation defect fill with PRF and PRF aspirin complex
时间窗: Baseline and six month postoperative
次要结局
- Regenerative capacity of PRF alone and PRF aspirin Complex(Base line and six month Postoperative)